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	Naringenin inhibits proliferation, migration, and invasion as well as induces apoptosis of gastric cancer SGC7901 cell line by downregulation of AKT pathway.
	The preliminary anti-cancer activity of Naringenin has been proven in several cancers. However; the therapeutic activity of Nar on gastric cancer SGC-7901 cell line is not yet well understood. The aim of the present study was to investigate the effect and mechanisms of Nar on proliferation; apoptosis; migration; and invasion of SGC-7901 cells. In this in vitro study; SGC-7901 cells were treated with Nar at serial concentrations. Our data showed that Nar efficiently inhibited SGC-7901 cell proliferation in a time- and concentration-dependent manner; as well as downregulated proliferating cell nuclear antigen levels in a concentration-dependent manner. Meanwhile; the cell migration and invasion also dramatically decreased after Nar incubation; and the expressions of MMP2 and MMP9 were significantly downregulated. In addition; a strong proapoptotic effect was observed in the SGC-7901 cells after Nar treatment. Apoptosis-related proteins Bax and cleaved caspase-3 were up-regulated
刊名	Tumour Biol
	2016
卷号	Vol.37 No.8页码:11365-11374
关键词	Gastric cancer Invasion Naringenin Proliferation Signal transduction pathway
ISSN号	1010-4283;1423-0380
URL标识	查看原文
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2003686
专题	河北省人民医院
作者单位	1.Department of General Surgery, The Fourth Affiliated Hospital, Hebei Medical University, No. 12, Jian-Kang Road, Shijiazhuang, 050011, China. li_yong_hbth@ 2.Department of General Surgery, The Fourth Affiliated Hospital, Hebei Medical University, No. 12, Jian-Kang Road, Shijiazhuang, 050011, China. 3.Sports St., Shijiazhuang, China. 4.Department of Gastroenterology, The Third Hospital of Shijiazhuang City, 5.Third Department of General Surgery, Hebei General Hospital, 6.He-Ping West St., Shijiazhuang, 050051, China. 7.com.
推荐引用方式 GB/T 7714	The preliminary anti-cancer activity of Naringenin has been proven in several cancers. However,the therapeutic activity of Nar on gastric cancer SGC-7901 cell line is not yet well understood. The aim of the present study was to investigate the effect and mechanisms of Nar on proliferation,apoptosis,et al. Naringenin inhibits proliferation, migration, and invasion as well as induces apoptosis of gastric cancer SGC7901 cell line by downregulation of AKT pathway.[J]. Tumour Biol,2016,Vol.37 No.8:11365-11374.
APA	The preliminary anti-cancer activity of Naringenin has been proven in several cancers. However.,the therapeutic activity of Nar on gastric cancer SGC-7901 cell line is not yet well understood. The aim of the present study was to investigate the effect and mechanisms of Nar on proliferation.,apoptosis.,migration.,and invasion of SGC-7901 cells. In this in vitro study.,...&and Nar might provide a new potential therapeutic strategy for treating gastric cancer..(2016).Naringenin inhibits proliferation, migration, and invasion as well as induces apoptosis of gastric cancer SGC7901 cell line by downregulation of AKT pathway..Tumour Biol,Vol.37 No.8,11365-11374.
MLA	The preliminary anti-cancer activity of Naringenin has been proven in several cancers. However,et al."Naringenin inhibits proliferation, migration, and invasion as well as induces apoptosis of gastric cancer SGC7901 cell line by downregulation of AKT pathway.".Tumour Biol Vol.37 No.8(2016):11365-11374.

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