Plasma phospholipid metabolic profiling and biomarkers of mouse IgA nephropathy

	Plasma phospholipid metabolic profiling and biomarkers of mouse IgA nephropathy
	Jia, Lewen ; Wang, Chang ; Kong, Hongwei ; Cai, Zongwei ; Xu, Guowang
刊名	metabolomics
	2006-06-01
卷号	2 期号:2 页码:95-104
关键词	metabonomics phospholipid IgA nephropathy intercellular adhesion molecule-1 high performance liquid chromatography mass spectrometry
通讯作者	许国旺
产权排序	1;1
英文摘要	iga nephropathy is the most common form of glomerulonephritis (gn) and it could progress to end-stage renal failure within 10 years. participating in biological processes in various pathways, phospholipids as a class of important constituents in the biomembranes have been paid increasing attention in many fields. however, phospholipids metabolism in glomerular disease was not clear, especially in iga nephropathy. in this paper, the plasma phospholipid metabolic profile in mouse iga nephropathy was investigated to discover the potential biomarkers on the progression of this disease by using high performance liquid chromatography/mass spectrometry (hplc/ms) and the principal components analysis (pca) as well as partial least squares-discriminant analysis (pls-da). the experimental mouse models of iga nephropathy were established by oral immune and bsa injection. it was found that expression of intercellular adhesion molecule-1 (icam-1) in the glomeruli had a significant correlation with proteinuria in mouse iga nephropathy. the association between plasma phospholipids and expression of icam-1 in the glomeruli of iga nephropathy suggested c18:0/ci8:0 ps (phosphatidylserine), c18:0/c22:5 ps (phosphatidylserine) and c18:0/ c20:4 pi (phosphatidylinositol) were possible biomarkers of iga nephropathy. the results show that the plasma phospholipid metabolic profiles from hplc/ms combining with pca and pls-da can be used not only to differentiate the iga nephropathy from the controls, but also to discover and identify the potential biomarkers.
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	endocrinology & metabolism
研究领域[WOS]	endocrinology & metabolism
关键词[WOS]	tandem mass-spectrometry ; liquid-chromatography ; rat urine ; metabonomics ; identification ; gene ; recognition ; expression ; diagnosis ; cancer
收录类别	SCI
原文出处	true
语种	英语
WOS记录号	WOS:000245261200005
公开日期	2010-11-30
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/97611]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China 2.Dalian Med Univ, Affiliated Hosp 1, Dept Nephrol, Dalian 116011, Peoples R China 3.Hong Kong Baptist Univ, Dept Chem, Kowloon, Hong Kong, Peoples R China
推荐引用方式 GB/T 7714	Jia, Lewen,Wang, Chang,Kong, Hongwei,et al. Plasma phospholipid metabolic profiling and biomarkers of mouse IgA nephropathy[J]. metabolomics,2006,2(2):95-104.
APA	Jia, Lewen,Wang, Chang,Kong, Hongwei,Cai, Zongwei,&Xu, Guowang.(2006).Plasma phospholipid metabolic profiling and biomarkers of mouse IgA nephropathy.metabolomics,2(2),95-104.
MLA	Jia, Lewen,et al."Plasma phospholipid metabolic profiling and biomarkers of mouse IgA nephropathy".metabolomics 2.2(2006):95-104.