Regulation by Dietary Carbohydrates of Intermediary Metabolism in Liver and Muscle of Two Isogenic Lines of Rainbow Trout

doi:10.3389/fphys.2018.01579

CORC > 武汉植物园 > 中国科学院武汉植物园

	Regulation by Dietary Carbohydrates of Intermediary Metabolism in Liver and Muscle of Two Isogenic Lines of Rainbow Trout
	Panserat, Stephane 4; Geurden, Inge 4; Quillet, Edwige 1; Dupont-Nivet, Mathilde 1; Corraze, Genevieve 4; Skiba-Cassy, Sandrine 4; Marandel, Lucie 4; Song, Xuerong 2,3,4
刊名	FRONTIERS IN PHYSIOLOGY
	2018-11-13
卷号	9 页码:12
关键词	glycolysis gloconeogeriesis fatty acid metabolism cholesterol metabolism mitochondrial metabolism genetic variability
ISSN号	1664-042X
DOI	10.3389/fphys.2018.01579
英文摘要	Rainbow trout (Oncorhynchus mykiss) is recognized as a typical "glucose-intolerant" fish, and the limits of dietary carbohydrate utilization have been investigated for many years. In this study, the objective was to test the molecular effects of dietary carbohydrates on intermediary metabolism in two major metabolic tissues, liver and muscle. Another objective was also to study if the response to carbohydrate intake depended on the genetic background. We fed two isogenic lines of rainbow trout (named A22h and N38h) with high carbohydrate diet (carbohydrate, 22.9%) or low carbohydrate diet (carbohydrate, 3.6%) for 12 weeks. Carbohydrates were associated with higher feed utilization owned by the well-known protein-sparing effect, with better fish growth performance. However, atypical regulation of glycolysis and gluconeogenesis in liver and absence of hk and glut4 induction in muscle, were also observed. Regarding the effects of carbohydrates on other metabolism, we observed an increased, at a molecular level, of hepatic cholesterol biosynthesis, fatty acid oxidation and mitochondrial energy metabolism. Genetic variability (revealed by the differences between the two isogenic lines) was observed for some metabolic genes especially for those involved in the EPA and DHA biosynthetic capacity. Finally, our study demonstrates that dietary carbohydrate not only affect glucose metabolism but also strongly impact the lipid and energy metabolism in liver and muscle of trout.
资助项目	European Union's Horizon 2020 research and innovation program[652831]
WOS研究方向	Physiology
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000450037500001
内容类型	期刊论文
源URL	[http://202.127.146.157/handle/2RYDP1HH/6128]
专题	中国科学院武汉植物园
通讯作者	Panserat, Stephane
作者单位	1.Univ Paris Saclay, AgroParisTech, INRA, GABI, Jouy En Josas, France 2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Hubei, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Univ Pau & Pays Adour, INRA, UPPA E2S, Nutr Metab Aquaculture Aquapole UMR1419, St Pee Sur Nivelle, France
推荐引用方式 GB/T 7714	Panserat, Stephane,Geurden, Inge,Quillet, Edwige,et al. Regulation by Dietary Carbohydrates of Intermediary Metabolism in Liver and Muscle of Two Isogenic Lines of Rainbow Trout[J]. FRONTIERS IN PHYSIOLOGY,2018,9:12.
APA	Panserat, Stephane.,Geurden, Inge.,Quillet, Edwige.,Dupont-Nivet, Mathilde.,Corraze, Genevieve.,...&Song, Xuerong.(2018).Regulation by Dietary Carbohydrates of Intermediary Metabolism in Liver and Muscle of Two Isogenic Lines of Rainbow Trout.FRONTIERS IN PHYSIOLOGY,9,12.
MLA	Panserat, Stephane,et al."Regulation by Dietary Carbohydrates of Intermediary Metabolism in Liver and Muscle of Two Isogenic Lines of Rainbow Trout".FRONTIERS IN PHYSIOLOGY 9(2018):12.