Identification of another primordial CD80/86 molecule in rainbow trout: Insights into the origin and evolution of CD80 and CD86 in vertebrates

doi:10.1016/j.dci.2018.08.007

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	Identification of another primordial CD80/86 molecule in rainbow trout: Insights into the origin and evolution of CD80 and CD86 in vertebrates
	Zhang, Yong-An 3,4,5; Wang, Peng 1,2; Zhang, Xiang-Yang 1,2; Zhang, Xu-Jie 3,4,5
刊名	DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
	2018-12-01
卷号	89 页码:73-82
关键词	CD80/86 Duplication Evolution Rainbow trout
ISSN号	0145-305X
DOI	10.1016/j.dci.2018.08.007
英文摘要	In mammals, the binding of distinct costimulatory ligands CD80 and CD86 to their receptors is essential for optimal T cell activation. Previous studies have shown that only a single CD80/86 gene exists in rainbow trout (termed rtCD80/86A) and other teleost fish, suggesting that CD80 and CD86 arose by gene duplication in the tetrapod branch, after the separation of fish and tetrapods. However, in this study, another CD80/86 gene has been cloned from rainbow trout, termed rtCD80/86B. The sequence identity between trout CD80/86 is significantly higher than that between CD80 and CD86 in tetrapods, indicating that CD80 and CD86 underwent divergent evolution in vertebrates, especially in tetrapods. Gene synteny analyses showed that the CD80 and CD86 genes are closely located in the same chromosome in tetrapods. However, CD80/86 genes are located in two distinct chromosomes in rainbow trout and Atlantic salmon, suggesting that salmonid CD80/86 genes arose by the salmonid-specific whole-genome duplication (WGD) event. Expression analysis showed that rtCD80/86A was more abundant and inducible than rtCD80/86B in various tissues, indicating the important role of rtCD80/86A in trout immunity. Interestingly, we found that head kidney B cells showed higher expression level of rtCD80/86A and rtCD80/86B when compared with the other leukocytes, suggesting a potential role for trout B cells as antigen-presenting cells (APCs).
资助项目	National Natural Science Foundation of China[31602184]
WOS研究方向	Fisheries ; Immunology ; Zoology
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000444932200009
内容类型	期刊论文
源URL	[http://202.127.146.157/handle/2RYDP1HH/5727]
专题	中国科学院武汉植物园
通讯作者	Zhang, Yong-An
作者单位	1.Univ Chinese Acad Sci, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Hydrobiol, Wuhan, Hubei, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 4.Huazhong Agr Univ, State Key Lab Agr Microbiol, Wuhan, Hubei, Peoples R China 5.Huazhong Agr Univ, Coll Fisheries, Wuhan, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Yong-An,Wang, Peng,Zhang, Xiang-Yang,et al. Identification of another primordial CD80/86 molecule in rainbow trout: Insights into the origin and evolution of CD80 and CD86 in vertebrates[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2018,89:73-82.
APA	Zhang, Yong-An,Wang, Peng,Zhang, Xiang-Yang,&Zhang, Xu-Jie.(2018).Identification of another primordial CD80/86 molecule in rainbow trout: Insights into the origin and evolution of CD80 and CD86 in vertebrates.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,89,73-82.
MLA	Zhang, Yong-An,et al."Identification of another primordial CD80/86 molecule in rainbow trout: Insights into the origin and evolution of CD80 and CD86 in vertebrates".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 89(2018):73-82.