Whole-Brain Mapping of the Inputs and Outputs of the Medial Part of the Olfactory Tubercle

doi:10.3389/fncir.2017.00052

CORC > 武汉植物园 > 中国科学院武汉植物园

	Whole-Brain Mapping of the Inputs and Outputs of the Medial Part of the Olfactory Tubercle
	Liu, Qing 2,3; He, Xiaobin 2,3; Wang, Jie 2,3; Wang, Huadong 2,3; Xu, Fuqiang 2,3,4,6; Zhang, Zhijian 1,2,3,4; Zhang, Hongruo 5; Wen, Pengjie 2,3; Zhu, Xutao 2,3; Wang, Li 2,3,4
刊名	FRONTIERS IN NEURAL CIRCUITS
	2017-07-28
卷号	11 页码:13
关键词	the medial part of the OT virus tracing tools D1R and D2R neurons neuronal circuitry whole-brain mapping
ISSN号	1662-5110
DOI	10.3389/fncir.2017.00052
英文摘要	The medial part of the olfactory tubercle (OT) is a brain structure located at the interface of the reward and olfactory system. It is closely related to pheromone-rewards, natural reinforcement, addiction and many other behaviors. However, the structure of the anatomic circuitry of the medial part of the OT is still unclear. In the present study, the medial part of the OT was found to be highly connected with a wide range of brain areas with the help of the pseudorabies virus tracing tool. In order to further investigate the detailed connections for specific neurons, another tracing tool - rabies virus was utilized for D1R-cre and D2R-cre mice. The D1R and D2R neurons in the medial part of the OT were both preferentially innervated by the olfactory areas, especially the piriform cortex, and both had similar direct input patterns. With the help of the adeno-associated virus labeling, it was found that the two subpopulations of neurons primarily innervate with the reward related brain regions, with slightly less axons projecting to the olfactory areas. Thus, the whole-brain input and output circuitry structures for specific types of neurons in the medial part of the OT were systematically investigated, and the results revealed many unique connecting features. This work could provide new insights for further study into the physiological functions of the medial part of the OT.
资助项目	Chinese Ministry of Science and Technology[2015CB755601] ; Chinese Ministry of Science and Technology[2015AA020508] ; Chinese Academy of Sciences[XDB02050005] ; National Natural Science Foundation of China[31400976] ; National Natural Science Foundation of China[31400945] ; National Natural Science Foundation of China[31400977]
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000406365200001
内容类型	期刊论文
源URL	[http://202.127.146.157/handle/2RYDP1HH/4318]
专题	中国科学院武汉植物园
通讯作者	Xu, Fuqiang
作者单位	1.Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Wuhan, Hubei, Peoples R China 2.Chinese Acad Sci, Ctr Brain Sci, Key Lab Magnet Resonance Biol Syst, Wuhan, Hubei, Peoples R China 3.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, CAS Ctr Excellence Brain Sci & Intelligence Techn, Wuhan, Hubei, Peoples R China 4.Wuhan Natl Lab Optoelect, Wuhan, Hubei, Peoples R China 5.Wuhan Univ, Coll Life Sci, Wuhan, Hubei, Peoples R China 6.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Liu, Qing,He, Xiaobin,Wang, Jie,et al. Whole-Brain Mapping of the Inputs and Outputs of the Medial Part of the Olfactory Tubercle[J]. FRONTIERS IN NEURAL CIRCUITS,2017,11:13.
APA	Liu, Qing.,He, Xiaobin.,Wang, Jie.,Wang, Huadong.,Xu, Fuqiang.,...&Wang, Li.(2017).Whole-Brain Mapping of the Inputs and Outputs of the Medial Part of the Olfactory Tubercle.FRONTIERS IN NEURAL CIRCUITS,11,13.
MLA	Liu, Qing,et al."Whole-Brain Mapping of the Inputs and Outputs of the Medial Part of the Olfactory Tubercle".FRONTIERS IN NEURAL CIRCUITS 11(2017):13.