Symmetry-breaking assembled porous calcite microspheres and their multiple dental applications

doi:10.1007/s40843-017-9038-5

	Symmetry-breaking assembled porous calcite microspheres and their multiple dental applications
	Ma, Ming 1; Yan, Yanhong 2; Qi, Chao 1; Qi, Shengcai 3; Chern, Shixiong 1; Shang, Guangwei 3; Wang, Raorao 3; Chen, Hangrong 1
刊名	Science China Materials
	2017
卷号	60 期号:6 页码:516-528
ISSN号	20958226
DOI	10.1007/s40843-017-9038-5
英文摘要	Biomedical applications of porous calcium carbonate (CaCO3) microspheres have been mainly restricted by their aqueous instability and low remineralization rate. To overcome these obstacles, a novel symmetry-breaking assembled porous calcite microsphere (PCMS) was constructed in an ethanol/water mixed system using a two-step vapor-diffusion/aging crystallization strategy. In contrast to the conventional additive-induced crystallization method, the present strategy was performed under mild conditions and was free from any foreign additives, thus avoiding the potential contamination of the final product. Meanwhile, the prepared PCMSs were characterized by their highly uniform spherical morphology and large open pores, which are favorable for large protein delivery. An antimicrobial study of immunoglobulin Y (IgY)-loaded PCMSs revealed excellent antimicrobial activity against Streptococcus mutans. More importantly, they showed surprisingly rapid transformation to bone minerals in physiological medium. Evaluation of the in vitro efficacy of PCMSs in dentinal tubule occlusion demonstrated their powerful potential to serve as a catalyst in the repair of dental hard tissue. Therefore, the developed PCMSs show great promise as multifunctional biomaterials for dental treatment applications. © 2017, Science China Press and Springer-Verlag GmbH Germany.
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/25618]
专题	中国科学院上海硅酸盐研究所
作者单位	1.State Key Lab of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China; 2.Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Department of Pediatric Dentistry, School of Stomatology, Tongji University, Shanghai; 200072, China; 3.Department of Stomatology, Shanghai Tenth People’s Hospital, Tongji University, Shanghai; 200072, China
推荐引用方式 GB/T 7714	Ma, Ming,Yan, Yanhong,Qi, Chao,et al. Symmetry-breaking assembled porous calcite microspheres and their multiple dental applications[J]. Science China Materials,2017,60(6):516-528.
APA	Ma, Ming.,Yan, Yanhong.,Qi, Chao.,Qi, Shengcai.,Chern, Shixiong.,...&Chen, Hangrong.(2017).Symmetry-breaking assembled porous calcite microspheres and their multiple dental applications.Science China Materials,60(6),516-528.
MLA	Ma, Ming,et al."Symmetry-breaking assembled porous calcite microspheres and their multiple dental applications".Science China Materials 60.6(2017):516-528.