Preparation and in vivo evaluation of a silicate-based composite bone cement

doi:10.1177/0885328217715428

	Preparation and in vivo evaluation of a silicate-based composite bone cement
	Ma, Bing 1; Huan, Zhiguang 1; Xu, Chen 1; Ma, Nan 2; Zhu, Haibo 2; Zhong, Jipin 3; Chang, Jiang 1
刊名	Journal of Biomaterials Applications
	2017
卷号	32 期号:2 页码:257-264
ISSN号	08853282
DOI	10.1177/0885328217715428
英文摘要	Silicate-based cements have been developed as a class of bioactive and biodegradable bone cements owing to their good in vitro bioactivity and ability to dissolve in a simulated body fluid. Until recently, however, the in vivo evidence of their ability to support bone regeneration is still scarce. In the present study, a pilot in vivo evaluation of a silicate-based composite bone cement (CSC) was carried out in a rabbit femur defect model. The cement was composed of tricalcium silicate, 45S5 bioglass and calcium sulfate, and the self-setting properties of the material were established. The in vivo bone integration and biodegradability of CSC were investigated and compared with those of bioactive glass particulates, and a calcium phosphate cement. The results showed that CSC underwent a relatively slower in vivo degradation as compared with bioactive glass and calcium phosphate cement. Histological observation demonstrated that bone contact area at the interface between the surrounding bone and CSC gradually increased with time proceeding. CSC kept its structural integrity during implantation in vivo because of its acceptable mechanical strength. These results provide evidence of effectiveness in vivo and suggest potential clinical applications of the silicate-based composite bone cements. © The Author(s) 2017.
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/25797]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai; 200050, China; 2.Central Hospital of Xuhui District, Shanghai, China; 3.Yancheng Beiersheng Biotecnology Co. Ltd, Jiangsu, China
推荐引用方式 GB/T 7714	Ma, Bing,Huan, Zhiguang,Xu, Chen,et al. Preparation and in vivo evaluation of a silicate-based composite bone cement[J]. Journal of Biomaterials Applications,2017,32(2):257-264.
APA	Ma, Bing.,Huan, Zhiguang.,Xu, Chen.,Ma, Nan.,Zhu, Haibo.,...&Chang, Jiang.(2017).Preparation and in vivo evaluation of a silicate-based composite bone cement.Journal of Biomaterials Applications,32(2),257-264.
MLA	Ma, Bing,et al."Preparation and in vivo evaluation of a silicate-based composite bone cement".Journal of Biomaterials Applications 32.2(2017):257-264.