Rapid Simultaneous Screening and Detection of 12 Anticoagulant Rodenticides in Food by Ultra-performance Liquid Chromatography-Triple Quadrupole/Linear Ion Trap Tandem Mass Spectrometry

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	Rapid Simultaneous Screening and Detection of 12 Anticoagulant Rodenticides in Food by Ultra-performance Liquid Chromatography-Triple Quadrupole/Linear Ion Trap Tandem Mass Spectrometry
	Cao, Xiaoli 1; Yang, Xiaoqian 1; Liu, Zhong 1; Jiao, Haitao 1; Liu, Suhua 1; Liu, Lanzheng 1; Meng, Qingfen 2
刊名	FOOD ANALYTICAL METHODS
	2017-11-01
卷号	10 期号:11 页码:3538-3547
关键词	Anticoagulant Rodenticides Multi-residue Analysis Modified Quechers Food Uplc-qtrap-ms/ms
文献子类	Article
英文摘要	A rapid analytical method for the simultaneous screening and detection of 12 anticoagulant rodenticides in food samples was established based on modified QuEChERS (quick, easy, cheap, effective, rugged, and safe) sample preparation method using an ultra-performance liquid chromatography-triple quadrupole/linear ion trap tandem mass spectrometry (UPLC-QTrap-MS/MS). Food samples were extracted and purified with modified QuEChERS method. The 12 anticoagulant rodenticides (warfarin, brodifacoum, difethialone, coumachlor, coumatetralyl, bromadiolone, chlorophacinone, difenacoum, diphacinone, pindone, valone, and flocoumafen) and the internal standard (warfarin-D-5) were separated within 6 min using an ACQUITY UPLC BEH-C18 column (1.7 mu m, 2.1 mm x 50 mm) and gradient elution with the mobile phase consisting of 5 mM ammonium acetate formate buffer and acetonitrile. The multiple reaction monitoring-information dependent acquisition-enhanced product ion (MRM-IDA-EPI) scanning was employed for detection. The calibration curves were linear (R (2) > 0.99) for all the compounds. The mean recoveries for the 12 analytes at three spiked levels (1x LOQ, 5x LOQ, and 10x LOQ) were in the range of 79.5-113.2% with RSDs of 1.8-13.2%.The limits of detection (LOD) for the 12 rodenticides ranged from 0.01 (warfarin) to 0.05 mu g/kg (diphacinone). The limit of quantification (LOQ) for the 12 rodenticides was between 0.02 (warfarin) and 0.10 mu g/kg (diphacinone). The developed method was more straightforward, less time and labor intensive, and more sensitive, selective, and accurate for screening multiple anticoagulant rodenticides, and it was successfully used in several poisoning cases.
WOS关键词	FLUORESCENCE DETECTION ; HUMAN SERUM ; WHOLE-BLOOD ; WASTE-WATER ; BRODIFACOUM ; LIVER ; BROMADIOLONE ; PLASMA ; HPLC ; INTOXICATION
WOS研究方向	Food Science & Technology
语种	英语
WOS记录号	WOS:000412116000006
内容类型	期刊论文
源URL	[http://ir.isl.ac.cn/handle/363002/6256]
专题	青海盐湖研究所_青海盐湖研究所知识仓储
作者单位	1.Jinan Municipal Ctr Dis Control & Prevent, Jinan 250021, Shandong, Peoples R China 2.Chinese Acad Sci, Qinghai Inst Salt Lakes, Xining 810008, Qinghai, Peoples R China
推荐引用方式 GB/T 7714	Cao, Xiaoli,Yang, Xiaoqian,Liu, Zhong,et al. Rapid Simultaneous Screening and Detection of 12 Anticoagulant Rodenticides in Food by Ultra-performance Liquid Chromatography-Triple Quadrupole/Linear Ion Trap Tandem Mass Spectrometry[J]. FOOD ANALYTICAL METHODS,2017,10(11):3538-3547.
APA	Cao, Xiaoli.,Yang, Xiaoqian.,Liu, Zhong.,Jiao, Haitao.,Liu, Suhua.,...&Meng, Qingfen.(2017).Rapid Simultaneous Screening and Detection of 12 Anticoagulant Rodenticides in Food by Ultra-performance Liquid Chromatography-Triple Quadrupole/Linear Ion Trap Tandem Mass Spectrometry.FOOD ANALYTICAL METHODS,10(11),3538-3547.
MLA	Cao, Xiaoli,et al."Rapid Simultaneous Screening and Detection of 12 Anticoagulant Rodenticides in Food by Ultra-performance Liquid Chromatography-Triple Quadrupole/Linear Ion Trap Tandem Mass Spectrometry".FOOD ANALYTICAL METHODS 10.11(2017):3538-3547.