A patterned nanocomposite membrane for high-efficiency healing of diabetic wound

doi:10.1039/c7tb00124j

	A patterned nanocomposite membrane for high-efficiency healing of diabetic wound
	Li, Jinyan 1,2; Lv, Fang 3; Xu, He 4; Zhang, Yali 2; Wang, Jie 4; Yi, Zhengfang 3; Yin, Jingbo 1; Chang, Jiang 2; Wu, Chengtie 2
刊名	Journal of Materials Chemistry B
	2017
卷号	5 期号:10 页码:1926-1934
ISSN号	20507518
DOI	10.1039/c7tb00124j
英文摘要	The highly efficient therapy of diabetic wounds represents a significant clinical challenge. To effectively stimulate angiogenesis and accelerate diabetic wound healing, we prepared a nanocomposite dressing that combined bioactive glass (BG) nanocoatings with a patterned electrospun membrane (BG/PEM) via a pulsed laser deposition (PLD) technique. The results showed that the BG nanocoatings had a homogeneous nanostructure and uniform elemental distribution including Ca, Si, and P. The surface hydrophilicity of the virgin PEM was significantly improved after the BG nanocoatings were deposited. An in vitro study showed that Si ions could be released from BG/PEM in a controlled profile. The proliferation, attachment, and expression of angiogenesis-related genes (endothelial nitric oxide synthase (eNos) and vascular endothelial growth factor (VEGF)) of human umbilical vein endothelial cells (HUVECs) on BG/PEM were significantly enhanced in comparison with those of the cells on the PEM. An in vivo study showed that diabetic mice wounds treated with BG/PEM had closed by nearly 80% at day 13, which is a significantly higher rate than that obtained with the PEM (57%) and control (56%) groups. Furthermore, wounds treated with BG/PEM displayed significantly improved efficiency in the stimulation of angiogenesis (indicated by CD31 expression and number of new blood vessels), as well as re-epithelialization. Overall, our results indicated that the BG/PEM nanocomposites were promising biomaterials for the rapid stimulation of angiogenesis and highly efficient healing of diabetic wounds. © The Royal Society of Chemistry.
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/25490]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Department of Polymer Materials, Shanghai University, 333 Nanchen Road, Shanghai; 200444, China; 2.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China; 3.Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai; 200241, China; 4.College of Life and Environment Sciences, Shanghai Normal University, Shanghai; 200234, China
推荐引用方式 GB/T 7714	Li, Jinyan,Lv, Fang,Xu, He,et al. A patterned nanocomposite membrane for high-efficiency healing of diabetic wound[J]. Journal of Materials Chemistry B,2017,5(10):1926-1934.
APA	Li, Jinyan.,Lv, Fang.,Xu, He.,Zhang, Yali.,Wang, Jie.,...&Wu, Chengtie.(2017).A patterned nanocomposite membrane for high-efficiency healing of diabetic wound.Journal of Materials Chemistry B,5(10),1926-1934.
MLA	Li, Jinyan,et al."A patterned nanocomposite membrane for high-efficiency healing of diabetic wound".Journal of Materials Chemistry B 5.10(2017):1926-1934.