Hydrophilic K2Mn4O8 nanoflowers as a sensitive photothermal theragnosis synergistic platform for the ablation of cancer | |
Peng, Yuxuan; Zhang, Fei1; Huang, Xiaojuan; Li, Bo2; Guan, Guoqiang; Zhang, Wenlong; Zou, Rujia; Lu, Xinwu3; Hu, Junqing | |
刊名 | NEW JOURNAL OF CHEMISTRY |
2018 | |
卷号 | 42期号:5页码:3714 |
ISSN号 | 1144-0546 |
DOI | 10.1039/c7nj04242f |
英文摘要 | Achieving cancer diagnosis and treatment simultaneously, multifunctional nanomaterials lead the trend in the development of nanomedicine. Manganese-based compounds have been well developed as excellent magnetic resonance (MR) imaging contrast agents, while they have not been demonstrated as photothermal agents (PTAs) due to their unsatisfactory near-infrared photoabsorption. Herein, we report a hydrophilic flower-like K2Mn4O8 superstructure self-assembled by ultrathin nanosheets that can work simultaneously as a PTA and an ultrasensitive T-1-weighted magnetic resonance imaging (T-1-MRI) enhancing agent. These K2Mn4O8 nanoflowers are efficient vehicles transforming 808 nm laser energy into thermal energy and then leading to the effective ablation of cancer cells in vitro and in vivo. Importantly, with a high longitudinal relaxivity (r(1)) of 4.6 mM(-1) s(-1), they also act as quite impressive T-1-MRI enhancing agents. Both in vitro and in vivo experiments confirmed their great biocompatibility, low toxicity and high photothermal conversion capability. This is the first application of K2Mn4O8 as a PTA and would hopefully promote other Mn-based theranostics. |
学科主题 | Chemistry, Multidisciplinary |
出版者 | ROYAL SOC CHEMISTRY |
WOS记录号 | WOS:000426488900063 |
资助机构 | Yuxuan Peng and Fei Zhang contributed equally to this work. This work was financially supported by the National Natural Science Foundation of China (Grant No. 51672044, 51472049 and 51602049), the Shanghai Pujiang Program (Grant No. 16PJ1400200), the Program Innovative Research Team in University (IRT_16R13), the DHU Distinguished Young Professor Program, the Fundamental Research Funds for the Central Universities, National Natural Science Foundation of China (Grant 51702348), the Postdoctoral Science Foundation of China (2017M610260) and Shanghai Sailing Program (17YF1421400). ; Yuxuan Peng and Fei Zhang contributed equally to this work. This work was financially supported by the National Natural Science Foundation of China (Grant No. 51672044, 51472049 and 51602049), the Shanghai Pujiang Program (Grant No. 16PJ1400200), the Program Innovative Research Team in University (IRT_16R13), the DHU Distinguished Young Professor Program, the Fundamental Research Funds for the Central Universities, National Natural Science Foundation of China (Grant 51702348), the Postdoctoral Science Foundation of China (2017M610260) and Shanghai Sailing Program (17YF1421400). |
内容类型 | 期刊论文 |
源URL | [http://ir.sic.ac.cn/handle/331005/25105] |
专题 | 中国科学院上海硅酸盐研究所 |
作者单位 | 1.Donghua Univ, Coll Mat Sci & Engn, State Key Lab Modificat Chem Fibers & Polymer Mat, Shanghai 201620, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Shanghai Gen Hosp, Ctr Trauma, Shanghai 201620, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 4.Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Vasc Surg, Shanghai 200011, Peoples R China |
推荐引用方式 GB/T 7714 | Peng, Yuxuan,Zhang, Fei,Huang, Xiaojuan,et al. Hydrophilic K2Mn4O8 nanoflowers as a sensitive photothermal theragnosis synergistic platform for the ablation of cancer[J]. NEW JOURNAL OF CHEMISTRY,2018,42(5):3714, 3721. |
APA | Peng, Yuxuan.,Zhang, Fei.,Huang, Xiaojuan.,Li, Bo.,Guan, Guoqiang.,...&Hu, Junqing.(2018).Hydrophilic K2Mn4O8 nanoflowers as a sensitive photothermal theragnosis synergistic platform for the ablation of cancer.NEW JOURNAL OF CHEMISTRY,42(5),3714. |
MLA | Peng, Yuxuan,et al."Hydrophilic K2Mn4O8 nanoflowers as a sensitive photothermal theragnosis synergistic platform for the ablation of cancer".NEW JOURNAL OF CHEMISTRY 42.5(2018):3714. |
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