Synergistic Sonodynamic/Chemotherapeutic Suppression of Hepatocellular Carcinoma by Targeted Biodegradable Mesoporous Nanosonosensitizers

doi:10.1002/adfm.201800145

	Synergistic Sonodynamic/Chemotherapeutic Suppression of Hepatocellular Carcinoma by Targeted Biodegradable Mesoporous Nanosonosensitizers
	Li, Zhenli ; Han, Jun ; Yu, Luodan 1; Qian, Xiaoqin 2; Xing, Hao ; Lin, Han 1; Wu, Mengchao ; Yang, Tian ; Chen, Yu 1
刊名	ADVANCED FUNCTIONAL MATERIALS
	2018
卷号	28 期号:26
关键词	chemotherapy hepatocellular carcinoma hollow structures mesoporous organosilica sonodynamic therapy
ISSN号	1616-301X
DOI	10.1002/adfm.201800145
英文摘要	Hepatocellular carcinoma (HCC) is one of the deadliest malignancies worldwide featured with the poor prognosis and high mortality in affected patients. Given its insensitivity to conventional systemic chemotherapy, the development of novel modalities for HCC management is highly urgent. Sonodynamic therapy (SDT) has gained considerable momentum in cancer therapy. Especially, through synergistic SDT/chemotherapy, SDT would enhance the chemotherapeutic process on inhibiting tumor growth, which holds great potential on combating HCC. In this work, we report on the design/fabrication of targeted biodegradable nanosonosensitizers based on hollow mesoporous organosilica nanoparticles (HMONs), followed by pore-engineering including covalent anchoring of protoporphyrin (PpIX, HMONs-PpIX) and conjugation of arginine-glycine-aspartic acid in order to specifically targeting HCC cells. Such nanosonosensitizers provide efficient loading and controllable stimuli-responsive release of chemotherapeutic agents for HCC-targeting chemotherapy, thus promoting an enhancing chemotherapeutic process via the unique sonotoxicity under ultrasound irradiation. The HMONs matrix with biologically active organic groups in the framework (disulfide bond) are endowed with intrinsic tumor microenvironment-responsive biodegradability and improved biocompatibility/biosafety. In particular, a synergistic inhibition effect of drug-loaded HMONs-PpIX-arginine-glycine-aspartic acid on HCC growth has been systematically demonstrated both in vitro and in vivo (84.7% inhibition rate), which brings insights and meets the versatile therapeutic requirements for HCC management.
学科主题	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000436104800009
资助机构	Z.L. and J.H. contributed equally to this work. The authors greatly acknowledge the financial support from the National Key R&D Program of China (Grant No. 2016YFA0203700), the National Natural Science Foundation of China (Grant Nos. 51722211, 51672303, 81472284, and 81672699), Program of Shanghai Subject Chief Scientist (Grant No. 18XD1404300), and Young Elite Scientist Sponsorship Program by CAST (Grant No. 2015QNRC001). ; Z.L. and J.H. contributed equally to this work. The authors greatly acknowledge the financial support from the National Key R&D Program of China (Grant No. 2016YFA0203700), the National Natural Science Foundation of China (Grant Nos. 51722211, 51672303, 81472284, and 81672699), Program of Shanghai Subject Chief Scientist (Grant No. 18XD1404300), and Young Elite Scientist Sponsorship Program by CAST (Grant No. 2015QNRC001).
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/24855]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Hepatobiliary Surg, Shanghai 200438, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Lab High Performance Ceram & Superfine Micr, Shanghai 200050, Peoples R China 3.Jiangsu Univ, Affiliated Peoples Hosp, Dept Ultrasound, Zhenjiang 212002, Peoples R China
推荐引用方式 GB/T 7714	Li, Zhenli,Han, Jun,Yu, Luodan,et al. Synergistic Sonodynamic/Chemotherapeutic Suppression of Hepatocellular Carcinoma by Targeted Biodegradable Mesoporous Nanosonosensitizers[J]. ADVANCED FUNCTIONAL MATERIALS,2018,28(26).
APA	Li, Zhenli.,Han, Jun.,Yu, Luodan.,Qian, Xiaoqin.,Xing, Hao.,...&Chen, Yu.(2018).Synergistic Sonodynamic/Chemotherapeutic Suppression of Hepatocellular Carcinoma by Targeted Biodegradable Mesoporous Nanosonosensitizers.ADVANCED FUNCTIONAL MATERIALS,28(26).
MLA	Li, Zhenli,et al."Synergistic Sonodynamic/Chemotherapeutic Suppression of Hepatocellular Carcinoma by Targeted Biodegradable Mesoporous Nanosonosensitizers".ADVANCED FUNCTIONAL MATERIALS 28.26(2018).