Mesoporous Silica Nanoparticles-Reinforced Hydrogel Scaffold together with Pinacidil Loading to Improve Stem Cell Adhesion

doi:10.1002/cnma.201800026

	Mesoporous Silica Nanoparticles-Reinforced Hydrogel Scaffold together with Pinacidil Loading to Improve Stem Cell Adhesion
	Wang, Ning 1; Ma, Ming ; Luo, Yu ; Liu, Tianzhi 1; Zhou, Peng 2; Qi, Shengcai 2; Xu, Yuanzhi 2; Chen, Hangrong
刊名	CHEMNANOMAT
	2018
卷号	4 期号:7 页码:631
关键词	carboxyl groups modified mesoporous silica nanocomposite hydrogel scaffold pinacidil loading stem cell adhesion
ISSN号	2199-692X
DOI	10.1002/cnma.201800026
英文摘要	Although hydrogels can be applied in mimicking the native extracellular matrix environment, they generally suffer from weak mechanical properties, as well as the lack of a sustained supply of nutrients or simulants to maintain cell functions, which severely limits their further practical applications. Aiming to address the aforementioned issues, a novel reinforced nanocomposite hydrogel (NC gel) is developed, which is composed of gelatin methacryloyl (GeIMA) and carboxyl-modified mesoporous silica nanoparticles (MSNsCOOH) together with pinacidil loading. The mechanical properties and pore size of the NC gel can be tunable with the addition of different amounts of MSNs-COOH. In addition, mesoporous channels of MSNs-COOH endow the prepared NC gel with good performance in piancidil loading and longterm sustained release, which greatly promotes the viability and adhesion of bone marrow mesenchymal stem cells (BMSCs) and achieves the long-term cell adhesion, spreading and viability of encapsulated BMSC cells in 7 days. This NC gel platform shows great promise for tissue engineering applications, including functional integration and efficient differentiation of stem cells upon transplantation.
学科主题	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000437269400004
资助机构	This work was funded by the National Key Research and Development Program of China (Grant No.2017YFB0702600, 2017YFB0702602), the National Natural Science Foundation of China (Grant No.51402329, 51772316, 81500806), Natural Science Foundation of Shanghai (Grant No.18ZR1444800). ; This work was funded by the National Key Research and Development Program of China (Grant No.2017YFB0702600, 2017YFB0702602), the National Natural Science Foundation of China (Grant No.51402329, 51772316, 81500806), Natural Science Foundation of Shanghai (Grant No.18ZR1444800).
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/24836]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Chinese Acad Sci Shanghai, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Stomatol, Shanghai 200072, Peoples R China
推荐引用方式 GB/T 7714	Wang, Ning,Ma, Ming,Luo, Yu,et al. Mesoporous Silica Nanoparticles-Reinforced Hydrogel Scaffold together with Pinacidil Loading to Improve Stem Cell Adhesion[J]. CHEMNANOMAT,2018,4(7):631, 641.
APA	Wang, Ning.,Ma, Ming.,Luo, Yu.,Liu, Tianzhi.,Zhou, Peng.,...&Chen, Hangrong.(2018).Mesoporous Silica Nanoparticles-Reinforced Hydrogel Scaffold together with Pinacidil Loading to Improve Stem Cell Adhesion.CHEMNANOMAT,4(7),631.
MLA	Wang, Ning,et al."Mesoporous Silica Nanoparticles-Reinforced Hydrogel Scaffold together with Pinacidil Loading to Improve Stem Cell Adhesion".CHEMNANOMAT 4.7(2018):631.