Environment-Friendly Synthesis of Trace Element Zn, Sr, and F Codoping Hydroxyapatite with Non-cytotoxicity and Improved Osteoblast Proliferation and Differentiation

doi:10.1007/s12011-017-1226-5

	Environment-Friendly Synthesis of Trace Element Zn, Sr, and F Codoping Hydroxyapatite with Non-cytotoxicity and Improved Osteoblast Proliferation and Differentiation
	Xiao, Shengjie 1; Wang, Ming 1; Wang, Liping 1; Zhu, Yingchun 1
刊名	BIOLOGICAL TRACE ELEMENT RESEARCH
	2018
卷号	185 期号:1 页码:148
关键词	Hydroxyapatite Codoping Trace element Proliferation and differentiation
ISSN号	0163-4984
DOI	10.1007/s12011-017-1226-5
英文摘要	Hydroxyapatite (HAp, Ca-10[PO4](6)[OH](2)) doped with numerous trace elements possesses sensational biochemical effects in natural bones. To study the biochemical function of Zn, Sr, and F elements, a series of neoteric HAp biomaterials with Zn, Sr, and F concentrations close to natural bones are firstly synthesized by one-pot hydrothermal method. These materials are characterized through powder X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscope (SEM). All the synthesized materials are HAp phase. The morphology of these materials is nanorods. The phenomenon that L929 cells can live even at 400 mu g/mL powder concentration indicates that these materials are non-cytotoxic. The active effects of samples on proliferation and differentiation of osteoblast cells (MC3T3-E1) are certified by MTT and alkaline phosphatase (ALP) activity assays. The adhesion and proliferation of osteoblast measurement manifest that amounts of MC3T3-E1 advances about 1.86 times for ZnSrF/HAp compared with undoped HAp. This achievement may inspire us on the artificial design of new-style bionic bone grafts using trace bioactive elements and also suggest its latent applications in orthopedic surgery and bone osseointegration.
学科主题	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
出版者	HUMANA PRESS INC
WOS记录号	WOS:000441120100018
资助机构	We gratefully acknowledge the financial support by the National Natural Science Foundation of China (No. 51232007, 51072217, 51572283) and the Science and Technology Commission of Shanghai Municipality: (No. 08JC1420700 and No. 11XD1405600). ; We gratefully acknowledge the financial support by the National Natural Science Foundation of China (No. 51232007, 51072217, 51572283) and the Science and Technology Commission of Shanghai Municipality: (No. 08JC1420700 and No. 11XD1405600).
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/24694]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Chinese Acad Sci, Key Lab Inorgan Coating Mat CAS, Shanghai Inst Ceram, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Xiao, Shengjie,Wang, Ming,Wang, Liping,et al. Environment-Friendly Synthesis of Trace Element Zn, Sr, and F Codoping Hydroxyapatite with Non-cytotoxicity and Improved Osteoblast Proliferation and Differentiation[J]. BIOLOGICAL TRACE ELEMENT RESEARCH,2018,185(1):148, 161.
APA	Xiao, Shengjie,Wang, Ming,Wang, Liping,&Zhu, Yingchun.(2018).Environment-Friendly Synthesis of Trace Element Zn, Sr, and F Codoping Hydroxyapatite with Non-cytotoxicity and Improved Osteoblast Proliferation and Differentiation.BIOLOGICAL TRACE ELEMENT RESEARCH,185(1),148.
MLA	Xiao, Shengjie,et al."Environment-Friendly Synthesis of Trace Element Zn, Sr, and F Codoping Hydroxyapatite with Non-cytotoxicity and Improved Osteoblast Proliferation and Differentiation".BIOLOGICAL TRACE ELEMENT RESEARCH 185.1(2018):148.