The prospect of layered double hydroxide as bone implants: A study of mechanical properties, cytocompatibility and antibacterial activity

doi:10.1016/j.clay.2018.08.020

	The prospect of layered double hydroxide as bone implants: A study of mechanical properties, cytocompatibility and antibacterial activity
	Peng, Feng 1; Wang, Donghui ; Zhang, Dongdong 1; Cao, Huiliang ; Liu, Xuanyong
刊名	APPLIED CLAY SCIENCE
	2018
卷号	165 页码:179
关键词	Layered double hydroxide Bone implants Elastic modulus Cytocompatibility Antibacterial activity
ISSN号	0169-1317
DOI	10.1016/j.clay.2018.08.020
英文摘要	With the ability to host anions or neutral drugs, layered double hydroxide (LDH) are hot spots in the field of biomaterials. Intensive works so far only have focused on their application in surface modification or injectable medicine. Yet, little literatures report the potential of LDH as bone implants. In the present study, four types of LDH (Mg-Al, Mg-Fe, Zn-Al and Zn-Fe) were prepared via a coprecipitation method. Our results showed that the synthetic LDH powders can be pressed into discs in the absence of binder. The discs can maintain their shape after immersed in culture medium for 10 days, not including Mg-Al LDH disc. The elastic modulus of all discs was between 9 and 35 GPa, which was close to cortical bone (5-23 GPa). Zn-Al LDH and Zn-Fe LDH showed higher cytotoxicity than Mg-Al LDH and Mg-Fe LDH whether in the form of suspension or extract. Furthermore, even up to 10 mg/mL, the extract of Mg-Al LDH and Mg-Fe LDH showed no cytotoxicity, while cells were totally died in the extract of Zn-Al LDH and Zn-Fe LDH. Compared with cells, bacterial showed an even lower tolerance concentration to Zn-Al LDH and Zn-Fe LDH. This study indicates that Mg-containing LDH show better cytotocompatibility, while Zn-containing LDH show better antibacterial property. With proper elastic modulus and controllable biological effect, LDH are promising to be used as bone implants.
学科主题	Chemistry, Physical ; Materials Science, Multidisciplinary ; Mineralogy
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000445980400020
资助机构	This work is financially supported by National Natural Science Foundation of China (31771044), the National Key Research and Development Program of China No. 2016YFC1100604, Shanghai Committee of Science and Technology, China (15441904900) and International Partnership Program of Chinese Academy of Sciences Grant No. GJHZ1850. ; This work is financially supported by National Natural Science Foundation of China (31771044), the National Key Research and Development Program of China No. 2016YFC1100604, Shanghai Committee of Science and Technology, China (15441904900) and International Partnership Program of Chinese Academy of Sciences Grant No. GJHZ1850.
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/24623]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Chinese Acad Sci, State Key Lab High Performance Ceram & Superfine, Shanghai Inst Ceram, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Peng, Feng,Wang, Donghui,Zhang, Dongdong,et al. The prospect of layered double hydroxide as bone implants: A study of mechanical properties, cytocompatibility and antibacterial activity[J]. APPLIED CLAY SCIENCE,2018,165:179, 187.
APA	Peng, Feng,Wang, Donghui,Zhang, Dongdong,Cao, Huiliang,&Liu, Xuanyong.(2018).The prospect of layered double hydroxide as bone implants: A study of mechanical properties, cytocompatibility and antibacterial activity.APPLIED CLAY SCIENCE,165,179.
MLA	Peng, Feng,et al."The prospect of layered double hydroxide as bone implants: A study of mechanical properties, cytocompatibility and antibacterial activity".APPLIED CLAY SCIENCE 165(2018):179.