Vancomycin-loaded titanium coatings with an interconnected micro-patterned structure for prophylaxis of infections: an in vivo study

doi:10.1039/c7ra12347g

	Vancomycin-loaded titanium coatings with an interconnected micro-patterned structure for prophylaxis of infections: an in vivo study
	Zhang, Hao ; Wang, Guangchao ; Liu, Peizhao ; Tong, Dake ; Ding, Chen ; Zhang, Zequan 1; Xie, Youtao 1; Tang, Hao ; Ji, Fang
刊名	RSC ADVANCES
	2018
卷号	8 期号:17 页码:9223
ISSN号	2046-2069
DOI	10.1039/c7ra12347g
英文摘要	Titanium (Ti) and its alloys are widely applied as orthopedic implants for hip and knee prostheses, fixation, and dental implants. However, Ti and its alloys are bioinert and susceptible to bacteria and biofilm formation. Thus, surface biofunctionalisation of Ti is essential for improving the biofunction of Ti. The current in vitro study indicated that calcium phosphate bone cement with vancomycin doped on micro-patterned Ti with a grid-like structure surface could preserve the property of inhibition of bacterial adhesion and biofilm formation while not affecting the osteogenic differentiation. The present study investigated whether the biological performance of the bactericidal effect is preserved in vivo. The rabbit osteomyelitis model with tibial medullary cavity placement of Ti rods was employed to analyze the antibacterial effect of vancomycin-loaded Ti coatings with interconnected micro-patterned structure (TV). Thirty female rabbits (N = 10) were used to establish the implant-associated infection. Prior to implanting the TO and TV rods into the medullary cavity of the Left tibia of the rabbits, 10(6) CFU mL(-1) methicillin-resistant Staphylococcus aureus (MRSA) was injected into the medullary cavity of the Left tibia of the rabbits. The sterile Ti rod (NT) was used as the blank control. After 3 weeks, bone pathology was evaluated using X-ray and micro-CT. The in vivo study proposed that TV has the potential for prophylaxis against MRSA infection. Thus, the interconnected micro-patterned structured Ti rods Loaded with vancomycin could be applied for preventing Ti implant-associated infections.
学科主题	Chemistry, Multidisciplinary
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000431972600025
资助机构	This work was supported by the grants from Shanghai Committee of Science and Technology Foundation (No. 13411951500). ; This work was supported by the grants from Shanghai Committee of Science and Technology Foundation (No. 13411951500).
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/24574]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Second Mil Med Univ, Changhai Hosp, Dept Orthoped, 168 Changhai Rd, Shanghai 200433, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, Key Lab Inorgan Coating Mat, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Hao,Wang, Guangchao,Liu, Peizhao,et al. Vancomycin-loaded titanium coatings with an interconnected micro-patterned structure for prophylaxis of infections: an in vivo study[J]. RSC ADVANCES,2018,8(17):9223, 9231.
APA	Zhang, Hao.,Wang, Guangchao.,Liu, Peizhao.,Tong, Dake.,Ding, Chen.,...&Ji, Fang.(2018).Vancomycin-loaded titanium coatings with an interconnected micro-patterned structure for prophylaxis of infections: an in vivo study.RSC ADVANCES,8(17),9223.
MLA	Zhang, Hao,et al."Vancomycin-loaded titanium coatings with an interconnected micro-patterned structure for prophylaxis of infections: an in vivo study".RSC ADVANCES 8.17(2018):9223.