Photoelectron Transfer at ZnTPyP Self-Assembly/TiO2 Interfaces for Enhanced Two-Photon Photodynamic Therapy

doi:10.1021/acsami.7b14451

	Photoelectron Transfer at ZnTPyP Self-Assembly/TiO2 Interfaces for Enhanced Two-Photon Photodynamic Therapy
	Liu, Yanyan ; Meng, Xianfu ; Wang, Han 1; Tang, Zhongmin 1; Zuo, Changjing 2; He, Mingyuan ; Bu, Wenbo 1
刊名	ACS APPLIED MATERIALS & INTERFACES
	2018
卷号	10 期号:2 页码:1492
关键词	ZSN photosemiconductor amorphous TiO2 core/shell nanocrystal two-photon type-1 PDT
ISSN号	1944-8244
DOI	10.1021/acsami.7b14451
英文摘要	Two-photon (TP) absorption nanomaterials are highly desirable for deep-tissue clinical diagnostics and orthotopic disease treatment. Here, a well-designed core/shell nanostructure was successfully synthesized with a ZnTPyP self-assembly nanocrystal (ZSN) inner core coated by a homogeneous TiO2 layer outside (ZSN-TO). The ZSN is a good photosemiconductor, showing both one-photon (OP) and TP absorption properties for red fluorescence emission and electron-hole pair generation; TiO2 with good biocompatibility acts as the electron acceptor, which can transfer photoelectron from ZSN to TiO2 for highly effective electron-hole separation, favoring the production of long-life superoxide anion (O-2(center dot-)) by electrons and oxygen and strong oxidizing hydroxyl radical (center dot OH) by holes and surrounding H2O. Once pretreated with ZSN-TO, the simultaneous OP-405 nm or TP-800 nm laser stimulation and fluorescent imaging of reactive oxygen species (ROS) showed dynamical and continuous generation of ROS in HeLa cells, with cytotoxicity significantly increasing via the type-1-like photodynamic therapy process. The results demonstrated that the combination of organic ZSN with inorganic TiO2 has great applications as an excellent photosensitizer for deep-tissue fluorescent imaging and noninvasive disease treatment via TP photodynamic therapy.
学科主题	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000423140400005
资助机构	This work has been financially supported by National Science Foundation for the Young Scientists of China (grant no. 51702211), National Funds for Distinguished Young Scientists of China (grant no. 51725202), National Natural Science Foundation of China (grant nos. 51372260, 81471714), and Shanghai Excellent Academic Leaders Program (grant no. 16XD1404000). ; This work has been financially supported by National Science Foundation for the Young Scientists of China (grant no. 51702211), National Funds for Distinguished Young Scientists of China (grant no. 51725202), National Natural Science Foundation of China (grant nos. 51372260, 81471714), and Shanghai Excellent Academic Leaders Program (grant no. 16XD1404000).
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/24547]
专题	中国科学院上海硅酸盐研究所
作者单位	1.East China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Coll Chem & Mol Engn, 3663 North Zhong Shan Rd, Shanghai 200062, Peoples R China 2.Chinese Acad Sci, State Key Lab High Performance Ceram & Superfine, Shanghai Inst Ceram, 1295 Ding Xi Rd, Shanghai 200050, Peoples R China 3.Changhai Hosp Shanghai, Dept Nucl Med, 168 Chang Hai Rd, Shanghai 200433, Peoples R China
推荐引用方式 GB/T 7714	Liu, Yanyan,Meng, Xianfu,Wang, Han,et al. Photoelectron Transfer at ZnTPyP Self-Assembly/TiO2 Interfaces for Enhanced Two-Photon Photodynamic Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(2):1492, 1498.
APA	Liu, Yanyan.,Meng, Xianfu.,Wang, Han.,Tang, Zhongmin.,Zuo, Changjing.,...&Bu, Wenbo.(2018).Photoelectron Transfer at ZnTPyP Self-Assembly/TiO2 Interfaces for Enhanced Two-Photon Photodynamic Therapy.ACS APPLIED MATERIALS & INTERFACES,10(2),1492.
MLA	Liu, Yanyan,et al."Photoelectron Transfer at ZnTPyP Self-Assembly/TiO2 Interfaces for Enhanced Two-Photon Photodynamic Therapy".ACS APPLIED MATERIALS & INTERFACES 10.2(2018):1492.