Metabolic engineering for the production of isoprene and isopentenol by Escherichia coli

doi:10.1007/s00253-018-9200-5

	Metabolic engineering for the production of isoprene and isopentenol by Escherichia coli
	Li, Meijie 1,2; Nian, Rui 1; Xian, Mo 1; Zhang, Haibo 1
刊名	APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
	2018-09-01
卷号	102 期号:18 页码:7725-7738
关键词	Isoprene Isopentenol MVA MEP Metabolic engineering
ISSN号	0175-7598
DOI	10.1007/s00253-018-9200-5
英文摘要	The biotechnological production of isoprene and isopentenol has recently been studied. Isoprene, which is currently made mainly from petroleum, is an important platform chemical for synthesizing pesticides, medicines, oil additives, fragrances, and more and is especially important in the rubber production industry. Isopentenols, which have better combustion properties than well-known biofuels (ethanol), have recently received more attention. Supplies of petroleum, the conventional source of isoprene and isopentenols, are unsustainable, and chemical synthesis processes could cause serious environmental problems. As an alternative, the biosynthesis of isoprene and isopentenols in cell factories is more sustainable and environmentally friendly. With a number of advantages over other microorganisms, Escherichia coli is considered to be a powerful workhorse organism for producing these compounds. This review will highlight the recent advances in metabolic engineering for isoprene and isopentenol production, especially using E. coli cell factories.
资助项目	National Natural Science Foundation of China (NSF)[31400084] ; Hainan's Key Project of Research and Development Plan[ZDYF2017155] ; Taishan Scholars Climbing Program of Shandong[TSPD20150210] ; Youth Innovation Promotion Association (CAS)[2017252]
WOS关键词	METHYLERYTHRITOL PHOSPHATE-PATHWAY ; HMG-COA REDUCTASE ; MEVALONATE PATHWAY ; BACILLUS-SUBTILIS ; CAROTENOID BIOSYNTHESIS ; DIPHOSPHATE SYNTHASE ; 4FE-4S PROTEIN ; EXPRESSION ; EMISSION ; PLANTS
WOS研究方向	Biotechnology & Applied Microbiology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000442570500007
资助机构	National Natural Science Foundation of China (NSF) ; Hainan's Key Project of Research and Development Plan ; Taishan Scholars Climbing Program of Shandong ; Youth Innovation Promotion Association (CAS)
内容类型	期刊论文
源URL	[http://ir.qibebt.ac.cn/handle/337004/11890]
专题	中国科学院青岛生物能源与过程研究所
通讯作者	Xian, Mo; Zhang, Haibo
作者单位	1.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Key Lab Biobased Mat, 135 Songling Rd, Qingdao 266101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Li, Meijie,Nian, Rui,Xian, Mo,et al. Metabolic engineering for the production of isoprene and isopentenol by Escherichia coli[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2018,102(18):7725-7738.
APA	Li, Meijie,Nian, Rui,Xian, Mo,&Zhang, Haibo.(2018).Metabolic engineering for the production of isoprene and isopentenol by Escherichia coli.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,102(18),7725-7738.
MLA	Li, Meijie,et al."Metabolic engineering for the production of isoprene and isopentenol by Escherichia coli".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 102.18(2018):7725-7738.