TBBPA and Its Alternatives Disturb the Early Stages of Neural Development by Interfering with the NOTCH and WNT Pathways

doi:10.1021/acs.est.8b00414

	TBBPA and Its Alternatives Disturb the Early Stages of Neural Development by Interfering with the NOTCH and WNT Pathways
	Yin, Nuoya 1,2; Liang, Shaojun 1,2; Liang, Shengxian 1,2; Yang, Renjun 1,2; Hu, Bowen 1,2; Qin, Zhanfen 1,2; Liu, Aifeng 3; Faiola, Francesco 1,2
刊名	ENVIRONMENTAL SCIENCE & TECHNOLOGY
	2018-05-01
卷号	52 期号:9 页码:5459-5468
ISSN号	0013-936X
DOI	10.1021/acs.est.8b00414
文献子类	Article
英文摘要	Tetrabromobisphenol A (TBBPA), as well as its alternatives Tetrabromobisphenol S (TBBPS) and Tetrachlorobisphenol A (TCBPA), are widely used halogenated flame retardants. Their high detection rates in human breast milk and umbilical cord serum have raised wide concerns about their adverse effects on human fetal development. In this study, we evaluated the cytotoxicity and neural developmental toxicity of TBBPA, TBBPS, and TCBPA with a mouse embryonic stem cell (mESC) system, at human body fluid and environmental relevant doses. All the three compounds showed similar trends in their cytotoxic effects. However, while TBBPA and TBBPS stimulated ESC neural differentiation, TCBPA significantly inhibited neurogenesis. Mechanistically, we demonstrated that, as far as the NOTCH (positive regulator) and WNT (negative regulator) pathways were concerned, TBBPA only partially and slightly disturbed them, whereas TBBPS significantly inhibited the WNT pathway, and TCBPA down-regulated the expression of NOTCH effectors but increased the WNT signaling, actions which both inhibited neural specification. In conclusion, our findings suggest that TBBPS and TCBPA may not be safe alternatives to TBBPA, and their toxicity need to be comprehensively evaluated.
WOS关键词	EMBRYONIC STEM-CELLS ; TETRABROMOBISPHENOL-A TBBPA ; CEREBELLAR GRANULE CELLS ; ONE-GENERATION REPRODUCTION ; BROMINATED FLAME-RETARDANT ; FREE-RADICAL FORMATION ; IN-VITRO ; BISPHENOL-A ; LARVAL ZEBRAFISH ; OXIDATIVE STRESS
WOS研究方向	Engineering ; Environmental Sciences & Ecology
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000431466500045
资助机构	Chinese Academy of Sciences Strategic Priority Research Program(XDB14040301) ; National Natural Science Foundation of China(21577166 ; Chinese Academy of Sciences Hundred Talent Program(29[2015]30) ; Key Research Program of Frontier Sciences, CAS(QYZDJ-SSW-DQC017) ; 21461142001)
内容类型	期刊论文
源URL	[http://ir.qibebt.ac.cn/handle/337004/11519]
专题	中国科学院青岛生物能源与过程研究所
通讯作者	Faiola, Francesco
作者单位	1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Qingdao Inst Biomass Energy & Bioproc Technol, CAS Key Lab Biobased Mat, Qingdao 266101, Peoples R China
推荐引用方式 GB/T 7714	Yin, Nuoya,Liang, Shaojun,Liang, Shengxian,et al. TBBPA and Its Alternatives Disturb the Early Stages of Neural Development by Interfering with the NOTCH and WNT Pathways[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2018,52(9):5459-5468.
APA	Yin, Nuoya.,Liang, Shaojun.,Liang, Shengxian.,Yang, Renjun.,Hu, Bowen.,...&Faiola, Francesco.(2018).TBBPA and Its Alternatives Disturb the Early Stages of Neural Development by Interfering with the NOTCH and WNT Pathways.ENVIRONMENTAL SCIENCE & TECHNOLOGY,52(9),5459-5468.
MLA	Yin, Nuoya,et al."TBBPA and Its Alternatives Disturb the Early Stages of Neural Development by Interfering with the NOTCH and WNT Pathways".ENVIRONMENTAL SCIENCE & TECHNOLOGY 52.9(2018):5459-5468.