Functional roles of Aves class-specific cis-regulatory elements on macroevolution of bird-specific features

doi:10.1038/ncomms14229

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	Functional roles of Aves class-specific cis-regulatory elements on macroevolution of bird-specific features
	Seki, Ryohei 1,2; Li, Cai 3,4,5; Fang, Qi 3,4; Hayashi, Shinichi 2,6; Egawa, Shiro 2; Hu, Jiang 3; Xu, Luohao 3; Pan, Hailin 3,4; Kondo, Mao 2; Sato, Tomohiko 2
刊名	NATURE COMMUNICATIONS
	2017-02-06
卷号	8
DOI	10.1038/ncomms14229
文献子类	Article
英文摘要	Unlike microevolutionary processes, little is known about the genetic basis of macroevolutionary processes. One of these magnificent examples is the transition from non-avian dinosaurs to birds that has created numerous evolutionary innovations such as self-powered flight and its associated wings with flight feathers. By analysing 48 bird genomes, we identified millions of avian-specific highly conserved elements (ASHCEs) that predominantly (> 99%) reside in non-coding regions. Many ASHCEs show differential histone modifications that may participate in regulation of limb development. Comparative embryonic gene expression analyses across tetrapod species suggest ASHCE-associated genes have unique roles in developing avian limbs. In particular, we demonstrate how the ASHCE driven avian-specific expression of gene Sim1 driven by ASHCE may be associated with the evolution and development of flight feathers. Together, these findings demonstrate regulatory roles of ASHCEs in the creation of avian-specific traits, and further highlight the importance of cis-regulatory rewiring during macroevolutionary changes.
WOS关键词	DIFFERENTIAL EXPRESSION ANALYSIS ; SEQUENCE COUNT DATA ; GENE-EXPRESSION ; PHYLOGENETIC ANALYSIS ; EVOLUTION ; MOUSE ; LIMB ; FEATHERS ; GENOMES ; DINOSAURS
WOS研究方向	Science & Technology - Other Topics
语种	英语
WOS记录号	WOS:000393338600001
资助机构	Strategic Priority Research Program of the Chinese Academy of Sciences(XDB13000000) ; Lundbeckfonden(R190-2014-2827 ; JSPS KAKENHI Grant(JP15H04374) ; Naito Foundation ; Next Generation World-Leading Researchers from the Cabinet Office, Government of Japan(LS007) ; JSPS KAKENHI(JP14J07050 ; Platform Project for Supporting in Drug Discovery and Life Science Research Platform for Dynamic Approaches to Living System from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) ; Japan Agency for Medical Research and Development (AMED) ; R52-5062) ; JP15J06859 ; JP15J06385)
内容类型	期刊论文
源URL	[http://124.16.247.212/handle/311034/7514]
专题	古脊椎动物与古人类研究所_图书馆1
作者单位	1.Natl Inst Genet, Genet Strains Res Ctr, Mammalian Genet Lab, 1111 Yata, Mishima, Shizuoka 4118540, Japan 2.Tohoku Univ, Grad Sch Life Sci, Dept Dev Biol & Neurosci, Aobayama 6-3, Sendai, Miyagi 9808578, Japan 3.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Peoples R China 4.China Natl GeneBank, BGI Shenzhen, Shenzhen 518083, Peoples R China 5.Univ Copenhagen, Nat Hist Museum Denmark, Ctr GeoGenet, DK-1350 Copenhagen, Denmark 6.Univ Minnesota, Dept Genet Cell Biol & Dev, 321 Church St SE, Minneapolis, MN 55455 USA 7.Tohoku Univ, Frontier Res Inst Interdisciplinary Sci FRIS, Aoba Ku, Aobayama 6-3, Sendai, Miyagi 9808578, Japan 8.Norwegian Univ Sci & Technol, Univ Museum, N-7491 Trondheim, Norway 9.Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA 10.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, Beijing 100044, Peoples R China
推荐引用方式 GB/T 7714	Seki, Ryohei,Li, Cai,Fang, Qi,et al. Functional roles of Aves class-specific cis-regulatory elements on macroevolution of bird-specific features[J]. NATURE COMMUNICATIONS,2017,8.
APA	Seki, Ryohei.,Li, Cai.,Fang, Qi.,Hayashi, Shinichi.,Egawa, Shiro.,...&Zhang, Guojie.(2017).Functional roles of Aves class-specific cis-regulatory elements on macroevolution of bird-specific features.NATURE COMMUNICATIONS,8.
MLA	Seki, Ryohei,et al."Functional roles of Aves class-specific cis-regulatory elements on macroevolution of bird-specific features".NATURE COMMUNICATIONS 8(2017).