A novel fish collagen scaffold as dural substitute

doi:10.1016/j.msec.2017.05.102

CORC > 青岛生物能源与过程研究所 > 中国科学院青岛生物能源与过程研究所 > 仿生能源与储能系统团队

	A novel fish collagen scaffold as dural substitute
	Li, Qing 1; Mu, Lanlan 1; Zhang, Fenghua 1; Sun, Yue 2; Chen, Quan 2; Xie, Cuicui 1; Wang, Hongmei 1
刊名	MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
	2017-11-01
卷号	80 页码:346-351
关键词	Fish Collagen Edc Crosslinking Dural Substitute
DOI	10.1016/j.msec.2017.05.102
文献子类	Article
英文摘要	The novel fish collagen scaffolds were prepared by lyophilization. The collagen sponges and chitosan were chemically cross-linked with the 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) as a cross-linking agent by pressing in one special mould. The collagen scaffolds were analyzed by scanning electron microscopy (SEM) and mechanical property, and the in vitro collagenase degradation was tested. The results revealed that the scaffold has a suitable porosity, elasticity and prevent fluid leakage, suggesting potential applications in the tissue engineered. In vitro collagenase degradation demonstrated that the collagen cross-linking with EDC by pressing played an important role in their resistance to biodegradation. Moreover, the scaffold proved excellent biocompatibility for the activity and proliferation of mouse embryonic fibroblasts cells (MEFs) in vitro. The rabbit dural defect model demonstrated that the scaffolds could prevent brain tissue adhesion, which reduce the opportunity of inflammation, facilitate the growth of fibroblasts and enhance the tissue regeneration and healing. The novel fish collagen scaffold as dural substitute, demonstrate a capability for using in the field of tissue engineering. (C) 2017 Published by Elsevier B.V.
WOS研究方向	Materials Science
语种	英语
WOS记录号	WOS:000410254400041
内容类型	期刊论文
源URL	[http://ir.qibebt.ac.cn/handle/337004/9742]
专题	青岛生物能源与过程研究所_仿生能源与储能系统团队
作者单位	1.Qingdao Chunghao Tissue Engn Co Ltd, Qingdao 266003, Shandong, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266101, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Li, Qing,Mu, Lanlan,Zhang, Fenghua,et al. A novel fish collagen scaffold as dural substitute[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2017,80:346-351.
APA	Li, Qing.,Mu, Lanlan.,Zhang, Fenghua.,Sun, Yue.,Chen, Quan.,...&Wang, Hongmei.(2017).A novel fish collagen scaffold as dural substitute.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,80,346-351.
MLA	Li, Qing,et al."A novel fish collagen scaffold as dural substitute".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 80(2017):346-351.