Improving phloroglucinol tolerance and production in Escherichia coli by GroESL overexpression

doi:10.1186/s12934-017-0839-x

	Improving phloroglucinol tolerance and production in Escherichia coli by GroESL overexpression
	Zhang, Rubing 1,2; Cao, Yujin 1; Liu, Wei 1; Xian, Mo 1; Liu, Huizhou 1
刊名	MICROBIAL CELL FACTORIES
	2017-12-19
卷号	16
关键词	Groesl Expression Level Tolerance Escherichia Coli Phloroglucinol
ISSN号	1475-2859
DOI	10.1186/s12934-017-0839-x
文献子类	Article
英文摘要	Background: Phloroglucinol is an important chemical which has been successfully produced by engineered Escherichia coli. However, the toxicity of phloroglucinol can enormously inhibit E. coli cell growth and viability, and the productivity is still too low and not economically feasible for industrial applications. Therefore, strain tolerance to toxic metabolites remains a key issue during the production of chemicals using biological processes.
WOS关键词	CLOSTRIDIUM-ACETOBUTYLICUM ; TRANSCRIPTIONAL ANALYSIS ; DIRECTED EVOLUTION ; SOLVENT TOLERANCE ; ACID TOLERANCE ; CHEMICALS ; BUTANOL ; STRESS ; MECHANISMS ; CHAPERONES
WOS研究方向	Biotechnology & Applied Microbiology
语种	英语
出版者	BIOMED CENTRAL LTD
WOS记录号	WOS:000418667400001
资助机构	National Natural Science Foundation of China(21572242) ; Taishan Scholars Climbing Program of Shandong(tspd20150210)
内容类型	期刊论文
源URL	[http://ir.qibebt.ac.cn/handle/337004/10493]
专题	中国科学院青岛生物能源与过程研究所
通讯作者	Xian, Mo; Liu, Huizhou
作者单位	1.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, Qingdao 266101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Rubing,Cao, Yujin,Liu, Wei,et al. Improving phloroglucinol tolerance and production in Escherichia coli by GroESL overexpression[J]. MICROBIAL CELL FACTORIES,2017,16.
APA	Zhang, Rubing,Cao, Yujin,Liu, Wei,Xian, Mo,&Liu, Huizhou.(2017).Improving phloroglucinol tolerance and production in Escherichia coli by GroESL overexpression.MICROBIAL CELL FACTORIES,16.
MLA	Zhang, Rubing,et al."Improving phloroglucinol tolerance and production in Escherichia coli by GroESL overexpression".MICROBIAL CELL FACTORIES 16(2017).