Structural Covariance of Gray Matter Volume in HIV Vertically Infected Adolescents

doi:10.1038/s41598-018-19290-5

	Structural Covariance of Gray Matter Volume in HIV Vertically Infected Adolescents
	Li, Jielan 2; Gui, Xi'en 3; Lin, Fuchun 1; Lei, Hao 1; Tu, Ning 2; Wang, Panying 2; Zhang, Jing 2; Wen, Zhi 2; Gao, Lei 2; Wu, Guangyao 2
刊名	SCIENTIFIC REPORTS
	2018-01-19
卷号	8
ISSN号	2045-2322
DOI	10.1038/s41598-018-19290-5
文献子类	Article
英文摘要	Human immunodeficiency virus (HIV) infection significantly affect neurodevelopmental and behavioral outcomes. We investigated whether alterations of gray matter organization and structural covariance networks with vertical HIV infection adolescents exist, by using the GAT toolbox. MRI data were analysed from 25 HIV vertically infected adolescents and 33 HIV-exposed-uninfected control participants. The gray matter volume (GMV) was calculated, and structural brain networks were reconstructed from gray matter co-variance. Gray matter losses were pronounced in anterior cingulate cortex (ACC), right pallidum, right occipital lobe, inferior parietal lobe, and bilateral cerebellum crus. The global brain network measures were not significantly different between the groups; however, the nodal alterations were most pronounced in frontal, temporal, basal ganglia, cerebellum, and temporal lobes. Brain hubs in the HIV-infected subjects increased in number and tended to shift to sensorimotor and temporal areas. In the HIV-infected subjects, decreased GMVs in ACC and bilateral cerebellum were related to lower Mini-Mental State Examination scores; the CD4 counts were positively related to the GMVs in ACC and sensorimotor areas. These findings suggest that focally reduced gray matter, disrupted nodal profiles of structural wirings, and a shift in hub distribution may represent neuroanatomical biomarkers of HIV infection on the developing brain.
WOS关键词	HUMAN CORTICAL NETWORKS ; BRAIN NETWORKS ; ANTIRETROVIRAL THERAPY ; THEORETICAL ANALYSIS ; MULTIPLE-SCLEROSIS ; SPATIAL STATISTICS ; PEDIATRIC HIV ; CHILDREN ; ORGANIZATION ; CEREBELLAR
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000422891000012
资助机构	National Natural Science Foundation of China (NSFC)(81171315 ; National Natural Science Foundation of China (NSFC)(81171315 ; 81227902) ; 81227902) ; National Natural Science Foundation of China (NSFC)(81171315 ; National Natural Science Foundation of China (NSFC)(81171315 ; 81227902) ; 81227902) ; National Natural Science Foundation of China (NSFC)(81171315 ; National Natural Science Foundation of China (NSFC)(81171315 ; 81227902) ; 81227902) ; National Natural Science Foundation of China (NSFC)(81171315 ; National Natural Science Foundation of China (NSFC)(81171315 ; 81227902) ; 81227902)
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/12782]
专题	中国科学院武汉物理与数学研究所
通讯作者	Wu, Guangyao
作者单位	1.Chinese Acad Sci, Natl Ctr Magnet Resonance Wuhan, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan, Hubei, Peoples R China 2.Wuhan Univ, Zhongnan Hosp, Dept Magnet Resonance Imaging, Wuhan, Hubei, Peoples R China 3.Wuhan Univ, Zhongnan Hosp, Dept Infect Dis, Wuhan, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Li, Jielan,Gui, Xi'en,Lin, Fuchun,et al. Structural Covariance of Gray Matter Volume in HIV Vertically Infected Adolescents[J]. SCIENTIFIC REPORTS,2018,8.
APA	Li, Jielan.,Gui, Xi'en.,Lin, Fuchun.,Lei, Hao.,Tu, Ning.,...&Wu, Guangyao.(2018).Structural Covariance of Gray Matter Volume in HIV Vertically Infected Adolescents.SCIENTIFIC REPORTS,8.
MLA	Li, Jielan,et al."Structural Covariance of Gray Matter Volume in HIV Vertically Infected Adolescents".SCIENTIFIC REPORTS 8(2018).