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	Monitoring Fluorinated Dendrimer-Based Self-Assembled Drug-Delivery Systems with F-19 Magnetic Resonance
	Jiang, Zhong-Xing1,2; Bo, Shaowei2; Yuan, Yaping3; Liu, Xin2; Chen, Shizhen3; Zhou, Xin3; Yang, Zhigang2; Li, Yu2
刊名	EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
	2017-08-17
期号	30页码:4461-4468
关键词	Self-assembly Drug Delivery Fluorine Dendrimers Stacking Interactions
DOI	10.1002/ejoc.201700566
文献子类	Article
英文摘要	Monitoring a drug-delivery system with an imaging modality is of great importance for detailed understanding of drug-delivery processes and for achieving optimal therapeutic effects. Here, novel fluorinated self-assembled dendrimers with a single F-19 NMR signal were conveniently synthesized on multigram scales, and F-19 magnetic resonance, including spectroscopy (F-19 NMR) and imaging (F-19 MRI), was used to monitor the fluorinated dendrimer-based self-assembled drug-delivery systems. It was found that F-19 NMR and F-19 MRI were convenient and sensitive tools to monitor the self-assembly and drug-loading processes and to detect weak interactions between the drug and the drug-delivery vehicle because changes in the self-assembly profile sensitively induced corresponding F-19 magnetic resonance responses.
WOS关键词	NMR-SPECTROSCOPY ; IMAGING AGENT ; MRI ; DESIGN ; TRANSITIONS ; PERFORMANCE ; AMPHIPHILE ; LIGANDS
WOS研究方向	Chemistry
语种	英语
WOS记录号	WOS:000407822200015
资助机构	National Key Research and Development Program of China(2016YFC1304704) ; National Key Research and Development Program of China(2016YFC1304704) ; National Natural Science Foundation of China(21372181 ; National Natural Science Foundation of China(21372181 ; State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics (Wuhan Institute of Physics and Mathematics) ; State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics (Wuhan Institute of Physics and Mathematics) ; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials (Donghua University) ; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials (Donghua University) ; 21402144 ; 21402144 ; 21572168) ; 21572168) ; National Key Research and Development Program of China(2016YFC1304704) ; National Key Research and Development Program of China(2016YFC1304704) ; National Natural Science Foundation of China(21372181 ; National Natural Science Foundation of China(21372181 ; State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics (Wuhan Institute of Physics and Mathematics) ; State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics (Wuhan Institute of Physics and Mathematics) ; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials (Donghua University) ; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials (Donghua University) ; 21402144 ; 21402144 ; 21572168) ; 21572168)
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/11316]
专题	武汉物理与数学研究所_磁共振应用研究部
作者单位	1.Donghua Univ, State Key Lab Modificat Chem Fibers & Polymer Mat, Shanghai 201620, Peoples R China 2.Wuhan Univ, Sch Pharmaceut Sci, Hubei Prov Engn & Technol Res Ctr Fluorinated Pha, Wuhan 430071, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Zhong-Xing,Bo, Shaowei,Yuan, Yaping,et al. Monitoring Fluorinated Dendrimer-Based Self-Assembled Drug-Delivery Systems with F-19 Magnetic Resonance[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2017(30):4461-4468.
APA	Jiang, Zhong-Xing.,Bo, Shaowei.,Yuan, Yaping.,Liu, Xin.,Chen, Shizhen.,...&Li, Yu.(2017).Monitoring Fluorinated Dendrimer-Based Self-Assembled Drug-Delivery Systems with F-19 Magnetic Resonance.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(30),4461-4468.
MLA	Jiang, Zhong-Xing,et al."Monitoring Fluorinated Dendrimer-Based Self-Assembled Drug-Delivery Systems with F-19 Magnetic Resonance".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .30(2017):4461-4468.

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