Biological effects of amphiphilic copolymer nanoparticle-encapsulated multi- target chemotherapeutic drugs on MCF-7 human breast cancer cells

doi:10.1007/s11306-017-1187-x

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	Biological effects of amphiphilic copolymer nanoparticle-encapsulated multi- target chemotherapeutic drugs on MCF-7 human breast cancer cells
	Wang, Yulan 2,5; Xu, Shan 2; Mujeeb, Ayeesha 1; Nie, Guangjun 1; Tang, Huiru 2,3,4; Hu, Yili 2; Zhang, Limin 2; Wang, Hai 1
刊名	METABOLOMICS
	2017-05-01
卷号	13 期号:5
关键词	Metabolomics Nuclear Magnetic Resonance (Nmr) Metabolic Response Co-delivery Of Drugs Nanotechnology
DOI	10.1007/s11306-017-1187-x
文献子类	Article
英文摘要	Introduction Amphiphilic copolymer nanoparticle-encapsulated multi-target chemotherapeutic drugs have attracted considerable attention due to their favorable drug efficiency and potential application prospect. Studies have shown that an amphiphilic copolymer, methoxypoly( ethylene glycol)poly( lactide-co-glycolide) modified with e-polylysine, and encapsulated with hydrophilic doxorubicin, hydrophobic paclitaxel and survivin siRNA profoundly improved the therapeutic effect both in vitro and in vivo.
WOS关键词	CHOLINE PHOSPHOLIPID-METABOLISM ; ENHANCED ANTITUMOR EFFICACY ; METHOTREXATE TREATMENT ; CELLULAR UPTAKE ; CO-DELIVERY ; O-GLCNAC ; DOXORUBICIN ; PACLITAXEL ; APOPTOSIS ; SURVIVIN
WOS研究方向	Endocrinology & Metabolism
语种	英语
WOS记录号	WOS:000399681400004
资助机构	National Natural Science Foundation of China(21675169 ; National Natural Science Foundation of China(21675169 ; National Distinguished Young Scientists program(31325010) ; National Distinguished Young Scientists program(31325010) ; Ministry of Science and Technology 973(2012CB934004) ; Ministry of Science and Technology 973(2012CB934004) ; 21175149 ; 21175149 ; 91439102 ; 91439102 ; 21375144) ; 21375144) ; National Natural Science Foundation of China(21675169 ; National Natural Science Foundation of China(21675169 ; National Distinguished Young Scientists program(31325010) ; National Distinguished Young Scientists program(31325010) ; Ministry of Science and Technology 973(2012CB934004) ; Ministry of Science and Technology 973(2012CB934004) ; 21175149 ; 21175149 ; 91439102 ; 91439102 ; 21375144) ; 21375144)
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/11293]
专题	武汉物理与数学研究所_磁共振应用研究部
作者单位	1.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, 11 ZhongGuanCun BeiYiTiao, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, West 30 XiaoHongShan, Wuhan 430071, Peoples R China 3.Fudan Univ, State Key Lab Genet Engn, Zhongshan Hosp, 2005 Songhu Rd, Shanghai 200438, Peoples R China 4.Fudan Univ, Shanghai Int Ctr Mol Phen, Sch Life Sci, Collaborat Innovat Ctr Genet & Dev, 2005 Songhu Rd, Shanghai 200438, Peoples R China 5.Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yulan,Xu, Shan,Mujeeb, Ayeesha,et al. Biological effects of amphiphilic copolymer nanoparticle-encapsulated multi- target chemotherapeutic drugs on MCF-7 human breast cancer cells[J]. METABOLOMICS,2017,13(5).
APA	Wang, Yulan.,Xu, Shan.,Mujeeb, Ayeesha.,Nie, Guangjun.,Tang, Huiru.,...&Wang, Hai.(2017).Biological effects of amphiphilic copolymer nanoparticle-encapsulated multi- target chemotherapeutic drugs on MCF-7 human breast cancer cells.METABOLOMICS,13(5).
MLA	Wang, Yulan,et al."Biological effects of amphiphilic copolymer nanoparticle-encapsulated multi- target chemotherapeutic drugs on MCF-7 human breast cancer cells".METABOLOMICS 13.5(2017).