QQ客服 官方微博 反馈留言

	A retinoraphe projection regulates serotonergic activity and looming-evoked defensive behaviour
	Tao, Qian5; Huang, Lu2,3; Yuan, Tifei4; Tan, Minjie2,3; Xi, Yue2,3; Hu, Yu2,3; Zhao, Zhikai2,3; Zheng, Jiajun2,3; Han, Yushui2,3; Xu, Fuqiang6
刊名	NATURE COMMUNICATIONS
	2017-03-31
卷号	8
DOI	10.1038/ncomms14908
文献子类	Article
英文摘要	Animals promote their survival by avoiding rapidly approaching objects that indicate threats. In mice, looming-evoked defensive responses are triggered by the superior colliculus (SC) which receives direct retinal inputs. However, the specific neural circuits that begin in the retina and mediate this important behaviour remain unclear. Here we identify a subset of retinal ganglion cells (RGCs) that controls mouse looming-evoked defensive responses through axonal collaterals to the dorsal raphe nucleus (DRN) and SC. Looming signals transmitted by DRN-projecting RGCs activate DRN GABAergic neurons that in turn inhibit serotoninergic neurons. Moreover, activation of DRN serotoninergic neurons reduces looming-evoked defensive behaviours. Thus, a dedicated population of RGCs signals rapidly approaching visual threats and their input to the DRN controls a serotonergic self-gating mechanism that regulates innate defensive responses. Our study provides new insights into how the DRN and SC work in concert to extract and translate visual threats into defensive behavioural responses.
WOS关键词	RETINAL GANGLION-CELLS ; DORSAL RAPHE NUCLEUS ; PROTEIN-COUPLED RECEPTORS ; INNATE FEAR ; IMPENDING COLLISION ; GABAERGIC NEURONS ; 5-HT1A RECEPTORS ; CONDITIONED FEAR ; RHESUS-MONKEYS ; VISUAL-STIMULI
WOS研究方向	Science & Technology - Other Topics
语种	英语
WOS记录号	WOS:000397881600001
资助机构	National Natural Science Foundation of China(31400942 ; National Natural Science Foundation of China(31400942 ; National Program on Key Basic Research Project of China (973 Program)(2014CB542205) ; National Program on Key Basic Research Project of China (973 Program)(2014CB542205) ; Guangdong Natural Science Foundation(2014A030313387 ; Guangdong Natural Science Foundation(2014A030313387 ; funds of Leading Talents of Guangdong ; funds of Leading Talents of Guangdong ; Programme of Introducing Talents of Discipline to Universities(B14036) ; Programme of Introducing Talents of Discipline to Universities(B14036) ; National Basic Research program(2015CB351800) ; National Basic Research program(2015CB351800) ; Fundamental Research Funds for the Central Universities Grant(21609101) ; Fundamental Research Funds for the Central Universities Grant(21609101) ; USA National Institutes of Health(R01 NS077003) ; USA National Institutes of Health(R01 NS077003) ; 81601969 ; 81601969 ; S2013040014831) ; S2013040014831) ; 31571091) ; 31571091) ; National Natural Science Foundation of China(31400942 ; National Natural Science Foundation of China(31400942 ; National Program on Key Basic Research Project of China (973 Program)(2014CB542205) ; National Program on Key Basic Research Project of China (973 Program)(2014CB542205) ; Guangdong Natural Science Foundation(2014A030313387 ; Guangdong Natural Science Foundation(2014A030313387 ; funds of Leading Talents of Guangdong ; funds of Leading Talents of Guangdong ; Programme of Introducing Talents of Discipline to Universities(B14036) ; Programme of Introducing Talents of Discipline to Universities(B14036) ; National Basic Research program(2015CB351800) ; National Basic Research program(2015CB351800) ; Fundamental Research Funds for the Central Universities Grant(21609101) ; Fundamental Research Funds for the Central Universities Grant(21609101) ; USA National Institutes of Health(R01 NS077003) ; USA National Institutes of Health(R01 NS077003) ; 81601969 ; 81601969 ; S2013040014831) ; S2013040014831) ; 31571091) ; 31571091)
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/10889]
专题	武汉物理与数学研究所_磁共振应用研究部
作者单位	1.Natl Inst Biol Sci, Zhongguancun Life Sci, Pk 7 Sci Pk Rd, Beijing 102206, Peoples R China 2.Jinan Univ, CNS Regenerat Collaborat Joint Lab, Minist Educ, Guangdong Hongkong Macau Inst CNS Regenerat, Guangzhou 510632, Guangdong, Peoples R China 3.Jinan Univ, Guangdong Key Lab Brain Funct & Dis, Guangzhou 510632, Guangdong, Peoples R China 4.Nanjing Normal Univ, Sch Psychol, Nanjing 210097, Jiangsu, Peoples R China 5.Jinan Univ, Sch Med, Dept Psychol, Guangzhou 510632, Guangdong, Peoples R China 6.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 7.Univ Nebraska, Sch Vet Med & Biomed Sci, Lincoln, NE 68583 USA 8.Peking Univ, Dept Anat, Sch Basic Med Sci, Beijing 100191, Peoples R China 9.Univ Nebraska, Med Ctr, Dept Ophthalmol & Visual Sci, 600 S 42nd St, Omaha, NE 68198 USA 10.Univ Hong Kong, Dept Ophthalmol, Hong Kong, Hong Kong, Peoples R China
推荐引用方式 GB/T 7714	Tao, Qian,Huang, Lu,Yuan, Tifei,et al. A retinoraphe projection regulates serotonergic activity and looming-evoked defensive behaviour[J]. NATURE COMMUNICATIONS,2017,8.
APA	Tao, Qian.,Huang, Lu.,Yuan, Tifei.,Tan, Minjie.,Xi, Yue.,...&Ren, Chaoran.(2017).A retinoraphe projection regulates serotonergic activity and looming-evoked defensive behaviour.NATURE COMMUNICATIONS,8.
MLA	Tao, Qian,et al."A retinoraphe projection regulates serotonergic activity and looming-evoked defensive behaviour".NATURE COMMUNICATIONS 8(2017).

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。