Saponins from Sanguisorba officinalis Improve Hematopoiesis by Promoting Survival through FAK and Erk1/2 Activation and Modulating Cytokine Production in Bone Marrow

doi:10.3389/fphar.2017.00130

	Saponins from Sanguisorba officinalis Improve Hematopoiesis by Promoting Survival through FAK and Erk1/2 Activation and Modulating Cytokine Production in Bone Marrow
	Li, BG; Chen, X; Chen, S (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Chengdu, Sichuan, Peoples R China.; Chen, S; Wu, ZL; Ji, JX; Gao, Y
刊名	FRONTIERS IN PHARMACOLOGY
	2017
卷号	8 页码:130（1-13）
关键词	Myelosuppression Hematopoiesis Sanguisorba OfficinaL.s L. Saponin Ziyuglycoside i Ziyuglycoside Ii Apoptosis Cytokine
DOI	10.3389/fphar.2017.00130
产权排序	1
文献子类	Article
英文摘要	Radix Sanguisorbae, the root of Sanguisorba officinalis L. is used as traditional Chinese medicine. In recent decades, it has been reported to be clinically effective against myelosuppression induced by chemotherapy and/or radiotherapy. However, the underlining mechanism has not been well studied. In this work, we evaluated the hematopoietic effect of total saponins from S. officinalis L. on myelosuppressive mice induced by cyclophosphamide and by(60)Co-gamma-irradiation and confirmed the therapeutic effect. Then, we found total saponins and their characteristic constituents Ziyuglycoside I and Ziyuglycoside II can inhibit apoptosis of TF-1 cells caused by cytokine deprivation, and promote survival of mouse bone marrow nuclear cells through focal adhesion kinase (FAK) and extracellular signal-regulated kinase 1/2 (Erk1/2) activation in vitro. In addition, they can down-regulate macrophage inflammatory protein 2 (MIP-2), platelet factor 4 (PF4) and P-selectin secretion, which are reported to be suppressive to hematopoiesis, both in vitro and in vivo. These results suggest that promotion of survival through FAK and Erk1/2 activation and inhibition of suppressive cytokines in the bone marrow is likely to be the pharmacological mechanism underlying the hematopoietic effect of saponins from S. officinalis L.
学科主题	Pharmacology & Pharmacy
语种	英语
资助机构	This research was supported by Institutes for Drug Discovery and Development, Chinese Academy of Sciences (No. CASIMM0420152013 and CASIMM0420151009) and national science and technology major project (No. 2014ZX09201021008). ; Institutes for Drug Discovery and Development ; This research was supported by Institutes for Drug Discovery and Development, Chinese Academy of Sciences (No. CASIMM0420152013 and CASIMM0420151009) and national science and technology major project (No. 2014ZX09201021008). ; Institutes for Drug Discovery and Development ; Chinese Academy of Sciences [CASIMM0420152013, CASIMM0420151009] ; Chinese Academy of Sciences [CASIMM0420152013, CASIMM0420151009] ; national science and technology major project [2014ZX09201021008] ; national science and technology major project [2014ZX09201021008] ; This research was supported by Institutes for Drug Discovery and Development, Chinese Academy of Sciences (No. CASIMM0420152013 and CASIMM0420151009) and national science and technology major project (No. 2014ZX09201021008). ; Institutes for Drug Discovery and Development ; This research was supported by Institutes for Drug Discovery and Development, Chinese Academy of Sciences (No. CASIMM0420152013 and CASIMM0420151009) and national science and technology major project (No. 2014ZX09201021008). ; Institutes for Drug Discovery and Development ; Chinese Academy of Sciences [CASIMM0420152013, CASIMM0420151009] ; Chinese Academy of Sciences [CASIMM0420152013, CASIMM0420151009] ; national science and technology major project [2014ZX09201021008] ; national science and technology major project [2014ZX09201021008]
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/29250]
专题	成都生物研究所_天然产物研究
通讯作者	Chen, S (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Chengdu, Sichuan, Peoples R China.
推荐引用方式 GB/T 7714	Li, BG,Chen, X,Chen, S ,et al. Saponins from Sanguisorba officinalis Improve Hematopoiesis by Promoting Survival through FAK and Erk1/2 Activation and Modulating Cytokine Production in Bone Marrow[J]. FRONTIERS IN PHARMACOLOGY,2017,8:130（1-13）.
APA	Li, BG.,Chen, X.,Chen, S .,Chen, S.,Wu, ZL.,...&Gao, Y.(2017).Saponins from Sanguisorba officinalis Improve Hematopoiesis by Promoting Survival through FAK and Erk1/2 Activation and Modulating Cytokine Production in Bone Marrow.FRONTIERS IN PHARMACOLOGY,8,130（1-13）.
MLA	Li, BG,et al."Saponins from Sanguisorba officinalis Improve Hematopoiesis by Promoting Survival through FAK and Erk1/2 Activation and Modulating Cytokine Production in Bone Marrow".FRONTIERS IN PHARMACOLOGY 8(2017):130（1-13）.