In vitro synergistic antibacterial activities of helvolic acid on multi-drug resistant Staphylococcus aureus

	In vitro synergistic antibacterial activities of helvolic acid on multi-drug resistant Staphylococcus aureus
	Qin, L; Li, BG; Guan, JF; Zhang, GL; Zhang, GL, Chinese Acad Sci, Chengdu Inst Biol, Chengdu, Peoples R China.
刊名	NATURAL PRODUCT RESEARCH
	2009
卷号	23 期号:4 页码:309_318
关键词	Helvolic Acid Synergistic Effect Multi-drug Resistance Staphylococcus Aureus
ISSN号	1478-6419
产权排序	1
英文摘要	An agar plate method was established to screen synergistic antibacterial agents other than -lactamase inhibitors. By using this method, a strain Aspergillus sp136 was selected for further studies. From the metabolites of this strain, a synergistic antibacterial compound was isolated by bioautographic TLC assay-guided fractionation and identified as helvolic acid. The synergistic effect of helvolic acid to penicillin was about 3 times that of clavulanic acid to penicillin in agar diffusion assay on Bacillus cereus. In checkerboard studies, helvolic acid exhibited synergistic effects with erythromycin on all tested multi-drug resistant Staphylococcus aureus and with penicillin and tetracycline on some multi-drug resistant S. aureus. A pattern of enhanced killing was also found in time-kill studies on multi-drug resistant S. aureus.
学科主题	Chemistry, Applied ; Chemistry, Medicinal
语种	英语
WOS记录号	WOS:000264337700001
公开日期	2011-07-08
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/18249]
专题	成都生物研究所_天然产物研究
通讯作者	Zhang, GL, Chinese Acad Sci, Chengdu Inst Biol, Chengdu, Peoples R China.
推荐引用方式 GB/T 7714	Qin, L,Li, BG,Guan, JF,et al. In vitro synergistic antibacterial activities of helvolic acid on multi-drug resistant Staphylococcus aureus[J]. NATURAL PRODUCT RESEARCH,2009,23(4):309_318.
APA	Qin, L,Li, BG,Guan, JF,Zhang, GL,&Zhang, GL, Chinese Acad Sci, Chengdu Inst Biol, Chengdu, Peoples R China..(2009).In vitro synergistic antibacterial activities of helvolic acid on multi-drug resistant Staphylococcus aureus.NATURAL PRODUCT RESEARCH,23(4),309_318.
MLA	Qin, L,et al."In vitro synergistic antibacterial activities of helvolic acid on multi-drug resistant Staphylococcus aureus".NATURAL PRODUCT RESEARCH 23.4(2009):309_318.