Physicochemical characterization of veronicafolin-beta-cyclodextrin and solubility enhancement of veronicafolin-HP-beta-cyclodextrin inclusion compound

	Physicochemical characterization of veronicafolin-beta-cyclodextrin and solubility enhancement of veronicafolin-HP-beta-cyclodextrin inclusion compound
	Yang, YS; Zhang, YP; Yang, AM; Lu, RH; Shi, YP; Shi, GF; Yang, YS, Chinese Acad Sci, Lanzhou Inst Chem Phys, Lanzhou 730000, Gansu, Peoples R China.
刊名	CHINESE JOURNAL OF CHEMISTRY
	2005
卷号	23 期号:6 页码:775_780
关键词	Veronicafolin Beta-cyclodextrin Inclusion Complex Hydroxypropyl-beta-cyclodextrin Improvement Of Solubility
ISSN号	1001-604X
产权排序	3
英文摘要	Inclusion complexation between veronicafolin, 3,5,4'-trihydroxy-6,7,3'-trimethoxyflavone, and beta-cyclodextrin (beta-CD) was investigated by using H-1 NMR, IR, X-ray diffraction, thermo gravimetric analysis (TGA), and elemental analysis in the solid slate. The elemental analysis showed that the complex (1 : 1) of flavonol-beta-CD center dot 20H(2)O with C 39.58% and H 5.75% has been formed. The phase solubility profile of the favonol by UV-Vis in solution in the presence of hydroxypfropyl-beta-cyclodextrin (HP-beta-CD) was classified as A(L)-type, indicating the formation of I :: I inclusion complex. And the calibration equation y = 24148x+ 0.0075 (r= 0.9999) and phase-solubility diagram y = 0.4738x-2.0X10(-7) 10(-7\) (r=0.9490) were obtained. Stability constant K, was calculated from the phase solubility diagram (K-s=4.5 X 10(6)). Solubility of the veronicafolin was enhanced in the presence of HP-beta-CD.
学科主题	Chemistry, Multidisciplinary
语种	英语
WOS记录号	WOS:000229408100024
公开日期	2011-07-08
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/17661]
专题	成都生物研究所_天然产物研究
通讯作者	Yang, YS, Chinese Acad Sci, Lanzhou Inst Chem Phys, Lanzhou 730000, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Yang, YS,Zhang, YP,Yang, AM,et al. Physicochemical characterization of veronicafolin-beta-cyclodextrin and solubility enhancement of veronicafolin-HP-beta-cyclodextrin inclusion compound[J]. CHINESE JOURNAL OF CHEMISTRY,2005,23(6):775_780.
APA	Yang, YS.,Zhang, YP.,Yang, AM.,Lu, RH.,Shi, YP.,...&Yang, YS, Chinese Acad Sci, Lanzhou Inst Chem Phys, Lanzhou 730000, Gansu, Peoples R China..(2005).Physicochemical characterization of veronicafolin-beta-cyclodextrin and solubility enhancement of veronicafolin-HP-beta-cyclodextrin inclusion compound.CHINESE JOURNAL OF CHEMISTRY,23(6),775_780.
MLA	Yang, YS,et al."Physicochemical characterization of veronicafolin-beta-cyclodextrin and solubility enhancement of veronicafolin-HP-beta-cyclodextrin inclusion compound".CHINESE JOURNAL OF CHEMISTRY 23.6(2005):775_780.