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	The role of chemerin/CMKLR1 signaling on pregnancy mice and gestational diabetes mellitus
	Chen Huang; Jian V. Zhang
	2017
会议日期	2017
会议地点	合肥
英文摘要	Mother with obesity or gestational diabetes mellitus(GDM) has highly risk to develop perinatal complications and metabolic syndrome later in life. The serum from GDM patient mothers was examined with higher circular chemerin, a novel adipokine dominate secreted from white fat tissue. It is currently unknown if maternal chemerin was positively related to GDM and fetal growth. We compared serum level of chemerin on different time point of pregnancy. The result indicated chemerin levels were significantly increased along with pregnancy. Furthermore, the expression and location of chemerin and its receptors on pregnancy day 18 demonstrated that chemerin was highly expressed in placenta and liver. At the same time, we constructed maternal over-nutrient and obese mice model, fed primiparous C57BL/7 mice with high fat diet during pregnancy. The chemerin in serum displayed high levels in high fat diet mice. During gestation day 12 to 16, treatment the obese mice with antagonist a-NETA, to the specific small molecule antagonist to chemerin receptor CMKLR1, improved the glucose impair demonstrated by IPGTT and fast glucose measurement. A-NETA also decreased the infant weight and infant/placenta ratio. In vitro, chemerin or CMKLR1 siRNA treatment on placenta trophoblast Bewo cell decreased protein levels for animo acid transportor protein SNAT and LAT, glucose transporter protein Glut1 and Glut3. These results indicated that chemerin may have positive correlation with GDM and fetus growths. CMKLR1 antagonist treatment will improve the syndrome induced by high fat diet induced obese mice, implying the pharmaceutical use of CMKLR1 small molecule compound antagonist on GDM treatment
语种	英语
内容类型	会议论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/12416]
专题	深圳先进技术研究院_医药所
作者单位	2017
推荐引用方式 GB/T 7714	Chen Huang,Jian V. Zhang. The role of chemerin/CMKLR1 signaling on pregnancy mice and gestational diabetes mellitus[C]. 见:. 合肥. 2017.

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