Photo-Inspired Antibacterial Activity and Wound Healing Acceleration by Hydrogel Embedded with Ag/Ag@AgCl/ZnO Nanostructures.

	Photo-Inspired Antibacterial Activity and Wound Healing Acceleration by Hydrogel Embedded with Ag/Ag@AgCl/ZnO Nanostructures.
	Mao, Congyang; Xiang, Yiming; Liu, Xiangmei; Cui, Zhenduo; Yang, Xianjin; Yeung, Kelvin Wai Kwok; Pan, Haobo; Wang, Xianbao; Chu, Paul K.; Wu, Shuilin
刊名	ACS NANO
	2017
文献子类	期刊论文
英文摘要	Ag/Ag@AgCl/ZnO hybrid nanostructures are embedded in a hydrogel by a simple two-step technique. The Ag/Ag@AgCl nanostructures are assembled in the hydrogel via ultraviolet light chemical reduction followed by incorporation of ZnO nanostructures by NaOH precipitation. The hydrogel accelerates wound healing and exhibits high antibacterial efficiency against both Escherichia coli and Staphylococcus aureus under visible light irradiation. The Ag/Ag@AgCl nanostructures enhance the photo catalytic and antibacterial activity of ZnO due to the enhancement of reactive oxygen species byvisible light. This hydrogel system kills 95.95% of E. coli and 98.49% of S. aureus within 20 min upon exposure to simulated visible light, and rapid sterilization plays a crucial role in wound healing. In addition, this system provides controllable, sustained release of silver and zinc ions over a period of 21 days arising from the reversible swelling shrinking transition of the hydrogel triggered by the changing pH value in the biological environment. About 90% Zn2+ release is observed in the acidic environment after 3 days, whereas only 10% Zn2+ release occurs in the neutral environment after 21 days. In vivo results show that release of Ag+ and Zn2+ stimulates the immune function to produce a large number of white blood cells and neutrophils (2-4 times more than the control), thereby producing the synergistic antibacterial effects and accelerated wound healing.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/12373]
专题	深圳先进技术研究院_医药所
作者单位	ACS NANO
推荐引用方式 GB/T 7714	Mao, Congyang,Xiang, Yiming,Liu, Xiangmei,et al. Photo-Inspired Antibacterial Activity and Wound Healing Acceleration by Hydrogel Embedded with Ag/Ag@AgCl/ZnO Nanostructures.[J]. ACS NANO,2017.
APA	Mao, Congyang.,Xiang, Yiming.,Liu, Xiangmei.,Cui, Zhenduo.,Yang, Xianjin.,...&Wu, Shuilin.(2017).Photo-Inspired Antibacterial Activity and Wound Healing Acceleration by Hydrogel Embedded with Ag/Ag@AgCl/ZnO Nanostructures..ACS NANO.
MLA	Mao, Congyang,et al."Photo-Inspired Antibacterial Activity and Wound Healing Acceleration by Hydrogel Embedded with Ag/Ag@AgCl/ZnO Nanostructures.".ACS NANO (2017).