Evaluation of an injectable bioactive borate glass cement to heal bone defects in a rabbit femoral condyle model.

	Evaluation of an injectable bioactive borate glass cement to heal bone defects in a rabbit femoral condyle model.
	Wang, Hui; Cui, Xu; Huang, Wenhai; Zhang, Yadong; Huang, Chengcheng; Yu, Zunxiong; Wang, Lei; Liu, Wenlong; Zhou, Jie; Wang, Ting
刊名	MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
	2017
文献子类	期刊论文
英文摘要	There is a need for synthetic biomaterials to heal bone defects using minimal invasive surgery. In the present study, an injectable cement composed of bioactive borate glass particles and a chitosan bonding solution was developed and evaluated for its capacity to heal bone defects in a rabbit femoral condyle model. The injectability and setting time of the cement in vitro decreased but the compressive strength increased (8 +/- 2 MPa to 31 +/- 2 MPa) as the ratio of glass particles to chitosan solution increased (from 1.0 g ml(-1) to 2.5 g ml(-1)). Upon immersing the cement in phosphate -buffered saline, the glass particles reacted and converted to hydroxyapatite, imparting bioactivity to the cement Osteoblastic MC3T3-E1 cells showed enhanced proliferation and alkaline phosphatase activity when incubated in media containing the soluble ionic product of the cement The bioactive glass cement showed a better capacity to stimulate bone formation in rabbit femoral condyle defects at 12 weeks postimplantation when compared to a commercial calcium sulfate cement The injectable bioactive borate glass cement developed in this study could provide a promising biomaterial to heal bone defects by minimal invasive surgery. (C) 2016 Elsevier B.V. All rights reserved.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/12352]
专题	深圳先进技术研究院_医药所
作者单位	MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
推荐引用方式 GB/T 7714	Wang, Hui,Cui, Xu,Huang, Wenhai,et al. Evaluation of an injectable bioactive borate glass cement to heal bone defects in a rabbit femoral condyle model.[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2017.
APA	Wang, Hui.,Cui, Xu.,Huang, Wenhai.,Zhang, Yadong.,Huang, Chengcheng.,...&Wang, Ting.(2017).Evaluation of an injectable bioactive borate glass cement to heal bone defects in a rabbit femoral condyle model..MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS.
MLA	Wang, Hui,et al."Evaluation of an injectable bioactive borate glass cement to heal bone defects in a rabbit femoral condyle model.".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017).