Decorated ultrathin bismuth selenide nanosheets as targeted theranostic agents for in vivo imaging guided cancer radiation therapy.

	Decorated ultrathin bismuth selenide nanosheets as targeted theranostic agents for in vivo imaging guided cancer radiation therapy.
	Xie, Hanhan ; Yu, Xue-Feng ; Chu, Paul K. ; Chen, Tianfeng; Song, Zhenhuan ; Chang, Yanzhou
刊名	NPG ASIA MATERIALS
	2017
文献子类	期刊论文
英文摘要	An efficient radiotherapeutic agent is synthesized using ultrathin two-dimensional 30-nm-wide and 2-nm-thick Bi2Se3 nanosheets (NSs) as a radiosensitizer. Chitosan (CS) and RGD peptide are employed to enhance the radiotherapy efficiency and biocompatibility. The Bi2Se3-CS-RGD NSs exhibit excellent targeting ability to alpha v beta 3 integrin-overexpressing cancer cells and potent radiosensitization efficiency with high stability. Detailed in vitro experiments show that the Bi2Se3-CS-RGD NSs enhance the sensitivity of HeLa cells to X-ray-induced cell death by inhibiting TrxR activities and activating downstream reactive oxygen species-mediated signaling pathways. In vivo experiments using intravenous or intratumor injection demonstrate that the Bi2Se3-CS-RGD NSs are more efficient tumor growth inhibitors compared to bare Bi2Se3 NSs. The multifunctionality of the NSs enables the use of photoacoustic imaging and magnetic resonance imaging to examine their targeting ability and therapeutic effects, respectively. In addition, the RGD-decorated Bi2Se3 NSs show much better in vivobiocompatibility and can be efficiently expelled from the body after 48 h post injection. This study reveals an effective and safe theranostic agent for next-generation cancer radiotherapy.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/12309]
专题	深圳先进技术研究院_医药所
作者单位	NPG ASIA MATERIALS
推荐引用方式 GB/T 7714	Xie, Hanhan , Yu, Xue-Feng , Chu, Paul K. ,et al. Decorated ultrathin bismuth selenide nanosheets as targeted theranostic agents for in vivo imaging guided cancer radiation therapy.[J]. NPG ASIA MATERIALS,2017.
APA	Xie, Hanhan , Yu, Xue-Feng , Chu, Paul K. , Chen, Tianfeng,Song, Zhenhuan ,& Chang, Yanzhou .(2017).Decorated ultrathin bismuth selenide nanosheets as targeted theranostic agents for in vivo imaging guided cancer radiation therapy..NPG ASIA MATERIALS.
MLA	Xie, Hanhan ,et al."Decorated ultrathin bismuth selenide nanosheets as targeted theranostic agents for in vivo imaging guided cancer radiation therapy.".NPG ASIA MATERIALS (2017).