Deciphering active biocompatibility of iron oxide nanoparticles from their intrinsic antagonism

doi:10.1007/s12274-017-1905-8

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Deciphering active biocompatibility of iron oxide nanoparticles from their intrinsic antagonism
	Wang, L ; Wang, ZJ ; Li, XM ; Zhang, Y ; Yin, M ; Li, J ; Song, HY ; Shi, JY ; Ling, DS ; Wang, LH
刊名	NANO RESEARCH
	2018
卷号	11 期号:5 页码:2746-2755
关键词	Mesenchymal Stem-cells Magnetic Nanoparticles Induced Autophagy Oxidative Stress Cancer-cells In-vitro Cytotoxicity Apoptosis Graphene Therapy
ISSN号	1998-0124
DOI	10.1007/s12274-017-1905-8
文献子类	期刊论文
英文摘要	Magnetite nanoparticles (Fe3O4 NPs) are a well proven biocompatible nanomaterial, which hold great promise in various biomedical applications. Interestingly, unlike conventional biocompatible materials (e.g., polyethylene glycol (PEG)) that are chemically and biologically inert in nature, Fe3O4 NPs are known to be catalytically active and exhibit prominent physiological effects. Herein, we report an "active", dynamic equilibrium mechanism for maintaining the cellular amenity of Fe3O4 NPs. We examined the effects of two types of iron oxide (magnetite and hematite) NPs in rat pheochromocytoma (PC12) cells and found that both induced stress responses. However, only Fe2O3 NPs caused significant programmed cell death; whereas Fe3O4 NPs are amenable to cells. We found that intrinsic catalase-like activity of Fe3O4 NPs antagonized the accumulation of toxic reactive oxygen species (ROS) induced by themselves, and thereby modulated the extent of cellular oxidative stress, autophagic activity, and programmed cell death. In line with this observation, we effectively reversed severe autophagy and cell death caused by Fe2O3 NPs via co-treatment with natural catalase. This study not only deciphers the distinct intrinsic antagonism of Fe3O4 NPs, but opens new routes to designing biocompatible theranostic nanoparticles with novel mechanisms.
语种	英语
WOS记录号	WOS:000431999700039
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/28957]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Wang, L 2.Wang, ZJ 3.Li, XM 4.Zhang, Y 5.Yin, M 6.Li, J 7.Song, HY 8.Shi, JY 9.Ling, DS 10.Wang, LH
推荐引用方式 GB/T 7714	Wang, L,Wang, ZJ,Li, XM,et al. Deciphering active biocompatibility of iron oxide nanoparticles from their intrinsic antagonism[J]. NANO RESEARCH,2018,11(5):2746-2755.
APA	Wang, L.,Wang, ZJ.,Li, XM.,Zhang, Y.,Yin, M.,...&Fan, CH.(2018).Deciphering active biocompatibility of iron oxide nanoparticles from their intrinsic antagonism.NANO RESEARCH,11(5),2746-2755.
MLA	Wang, L,et al."Deciphering active biocompatibility of iron oxide nanoparticles from their intrinsic antagonism".NANO RESEARCH 11.5(2018):2746-2755.