Influences of mesoporous zinc-calcium silicate on water absorption, degradability, antibacterial efficacy, hemostatic performances and cell viability to microporous starch based hemostat

doi:10.1016/j.msec.2017.03.094

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Influences of mesoporous zinc-calcium silicate on water absorption, degradability, antibacterial efficacy, hemostatic performances and cell viability to microporous starch based hemostat
	Hou, Y; Xia, Y; Pan, YK; Tang, SC; Sun, XF; Xie, Y; Guo, H; Wei, J
刊名	MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
	2017
卷号	76 期号:-页码:340-349
关键词	Lethal Groin Injury Hemorrhage Control Agents Chitosan Battlefield Infection Dressings Sponge Model
ISSN号	0928-4931
DOI	10.1016/j.msec.2017.03.094
文献子类	期刊论文
英文摘要	Efficacious hemostatic agents have significant potential application in visceral organ or large vessel arterial injure. In this study, mesoporous zinc-calcium silicate (m-ZCS) was synthesized, and microporous starch (MS) based hemostatic agents of m-ZCS/MS composites for hemorrhage control was fabricated. The results showed that the incorporation of m-ZCS into MS significantly enhanced the water absorption and degradability of the composites, which were dependent on the m-ZCS content Moreover, the composites with antibacterial property could inhibit the growth of Escherichia coli (E. coli) and the antibacterial ratios increased with the m-ZCS content. The in vitro coagulation evaluation by using activated partial thromboplastin time (APTT) and prothrombin time (PT) revealed that the composites significantly activated the intrinsic and extrinsic pathway of coagulation cascade. In addition, for the animal model of rabbits in ear vein, skin, arterial and liver injuries, the hemostatic time of the composites obviously reduced with the increase of m-ZSC content, in which the composite with 15 wt% m-ZCS content (15mZSC) showed remarkable efficacy on bleeding control. The composites could promote the viability of L929 cells,.indicating no cytotoxicity of the composites. The results suggested that the m-ZCS/MS composites with excellent hemostatic and antibacterial properties might be a candidate for controlling bleeding and infection. 2017 Published by Elsevier B.V.
WOS关键词	LETHAL GROIN INJURY ; HEMORRHAGE CONTROL ; AGENTS ; CHITOSAN ; BATTLEFIELD ; INFECTION ; DRESSINGS ; SPONGE ; MODEL
语种	英语
WOS记录号	WOS:000405541600041
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/28701]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
推荐引用方式 GB/T 7714	Hou, Y,Xia, Y,Pan, YK,et al. Influences of mesoporous zinc-calcium silicate on water absorption, degradability, antibacterial efficacy, hemostatic performances and cell viability to microporous starch based hemostat[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2017,76(-):340-349.
APA	Hou, Y.,Xia, Y.,Pan, YK.,Tang, SC.,Sun, XF.,...&Wei, J.(2017).Influences of mesoporous zinc-calcium silicate on water absorption, degradability, antibacterial efficacy, hemostatic performances and cell viability to microporous starch based hemostat.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,76(-),340-349.
MLA	Hou, Y,et al."Influences of mesoporous zinc-calcium silicate on water absorption, degradability, antibacterial efficacy, hemostatic performances and cell viability to microporous starch based hemostat".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 76.-(2017):340-349.