A Membrane-Intercalating Conjugated Oligoelectrolyte with High-Efficiency Photodynamic Antimicrobial Activity

	A Membrane-Intercalating Conjugated Oligoelectrolyte with High-Efficiency Photodynamic Antimicrobial Activity
	Wang, Bing 1; Wang, Ming 1; Mikhailovsky, Alexander 1; Wang, Shu 2; Bazan, Guillermo C.1
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2017-04-24
卷号	56 期号:18 页码:5031-5034
关键词	Biocidal Activity Conjugated Oligoelectrolyte Membrane Intercalating Photodynamic Antimicrobial Therapy
英文摘要	A membrane-intercalating conjugated oligoelectrolyte (COE), PTTP, was designed and synthesized with the goal of providing red-shifted absorption spectra relative to previously synthesized COE analogs. Specifically, electron-rich and electron-poor subunits were introduced in the conjugated backbone to modulate the band gap. PTTP exhibits maxima of absorption at 507 nm and of emission at 725 nm. PTTP can also efficiently function to generate singlet oxygen in situ (Phi(Delta) approximate to 20%) and has appropriate topology and dimensions to interact with lipid membranes. The resulting rapid membrane insertion and sensitizing ability provide PTTP with a highly efficient antibacterial capability under a low light dose (0.6 J cm(-2)) toward Gram-negative bacteria E. coli, making it a remarkably efficient optically mediated antimicrobial agent.
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/38345]
专题	化学研究所_有机固体实验室
作者单位	1.Univ Calif Santa Barbara, Ctr Polymers & Organ Solids, Dept Chem & Biochem, Santa Barbara, CA 93106 USA 2.Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Wang, Bing,Wang, Ming,Mikhailovsky, Alexander,et al. A Membrane-Intercalating Conjugated Oligoelectrolyte with High-Efficiency Photodynamic Antimicrobial Activity[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2017,56(18):5031-5034.
APA	Wang, Bing,Wang, Ming,Mikhailovsky, Alexander,Wang, Shu,&Bazan, Guillermo C..(2017).A Membrane-Intercalating Conjugated Oligoelectrolyte with High-Efficiency Photodynamic Antimicrobial Activity.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,56(18),5031-5034.
MLA	Wang, Bing,et al."A Membrane-Intercalating Conjugated Oligoelectrolyte with High-Efficiency Photodynamic Antimicrobial Activity".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 56.18(2017):5031-5034.