Reductive formylation of amines with CO2 using sodium borohydride: A catalyst-free route

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	Reductive formylation of amines with CO2 using sodium borohydride: A catalyst-free route
	Hao, Leiduan 1; Zhang, Hongye 1; Luo, Xiaoying 1,2; Wu, Cailing 1,2; Zhao, Yanfei 1; Liu, Xinwei 1,2; Gao, Xiang 1,2; Chen, Yu 1,2; Liu, Zhimin 1,2
刊名	JOURNAL OF CO2 UTILIZATION
	2017-12-01
卷号	22 页码:208-211
关键词	Sodium Borohydride Reductive Formylation Carbon Dioxide Amine Reductive Cyclization
英文摘要	Using sodium borohydride (NaBH4) as the reducing reagent, the reductive fomylation of amines with CO2 was realized at 100 degrees C under catalyst-free conditions, and a series of formylated products were obtained in excellent yields. The reaction mechanism investigation demonstrated that NaBH4 could react with CO2 to form intermediate, which further reacted with amines, producing the formylated compounds. It was indicated that three hydrogen atoms from NaBH4 could involve in the reductive formylation, and therefore only 0.5 equiv. NaBH4 relative to the substrate was enough for getting high product yields. In addition, NaBH4 was also very efficient for the reductive cyclization of o-phenylenediamine with CO2 to synthesize benzimidazoles. NaBH4 as an efficient reducing reagent for the CO2-involed reductive reactions may have promising applications.
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/38317]
专题	化学研究所_胶体、界面与化学热力学实验室
作者单位	1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Colloid Interface & Thermodynam, CAS Res Educ Ctr Excellence Mol Sci,Inst Chem, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Hao, Leiduan,Zhang, Hongye,Luo, Xiaoying,et al. Reductive formylation of amines with CO2 using sodium borohydride: A catalyst-free route[J]. JOURNAL OF CO2 UTILIZATION,2017,22:208-211.
APA	Hao, Leiduan.,Zhang, Hongye.,Luo, Xiaoying.,Wu, Cailing.,Zhao, Yanfei.,...&Liu, Zhimin.(2017).Reductive formylation of amines with CO2 using sodium borohydride: A catalyst-free route.JOURNAL OF CO2 UTILIZATION,22,208-211.
MLA	Hao, Leiduan,et al."Reductive formylation of amines with CO2 using sodium borohydride: A catalyst-free route".JOURNAL OF CO2 UTILIZATION 22(2017):208-211.