Construction of Tough, in Situ Forming Double-Network Hydrogels with Good Biocompatibility

	Construction of Tough, in Situ Forming Double-Network Hydrogels with Good Biocompatibility
	Bu, Yazhong 1,2; Shen, Hong 1; Yang, Fei 1,2; Yang, Yanyu 1,2; Wang, Xing 1; Wu, Decheng 1,2
刊名	ACS APPLIED MATERIALS & INTERFACES
	2017-01-25
卷号	9 期号:3 页码:2205-2212
关键词	Peg Agarose Hydrogels Double Network Biocompatible
英文摘要	Hydrogels are required to have high mechanical properties, biocompatibility, and an easy fabrication process for biomedical applications. Double-network hydrogels, although strong, are limited because of the complicated preparation steps and toxic materials involved. In this study, we report a simple method to prepare tough, in situ forming polyethylene glycol (PEG) agarose double-network (PEG agarose DN) hydrogels with good biocompatibility. The hydrogels display excellent mechanical strength. Because of the easily in situ forming method, the resulting hydrogels can be molded into any form as needed. In vitro and in vivo experiments illustrate that the hydrogels exhibit satisfactory biocompatibility, and cells can attach and spread on the hydrogels. Furthermore, the residual amino groups in the network can also be functionalized for various biomedical applications in tissue engineering and cell research.
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/38072]
专题	化学研究所_高分子物理与化学实验室
作者单位	1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Bu, Yazhong,Shen, Hong,Yang, Fei,et al. Construction of Tough, in Situ Forming Double-Network Hydrogels with Good Biocompatibility[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(3):2205-2212.
APA	Bu, Yazhong,Shen, Hong,Yang, Fei,Yang, Yanyu,Wang, Xing,&Wu, Decheng.(2017).Construction of Tough, in Situ Forming Double-Network Hydrogels with Good Biocompatibility.ACS APPLIED MATERIALS & INTERFACES,9(3),2205-2212.
MLA	Bu, Yazhong,et al."Construction of Tough, in Situ Forming Double-Network Hydrogels with Good Biocompatibility".ACS APPLIED MATERIALS & INTERFACES 9.3(2017):2205-2212.