Boronlectin/Polyelectrolyte Ensembles as Artificial Tongue: Design, Construction, and Application for Discriminative Sensing of Complex Glycoconjugates from Panax ginseng

	Boronlectin/Polyelectrolyte Ensembles as Artificial Tongue: Design, Construction, and Application for Discriminative Sensing of Complex Glycoconjugates from Panax ginseng
	Zhang, Xiao-tai 1; Wang, Shu 2; Xing, Guo-wen 1
刊名	ACS APPLIED MATERIALS & INTERFACES
	2017-02-01
卷号	9 期号:4 页码:3368-3375
关键词	Ginsenosides Boronic Acid Polyelectrolyte Sensor Array Pattern Recognition
英文摘要	Ginsenoside is a large family of triterpenoid saponins from Panax ginseng, which possesses various important biological functions. Due to the very similar structures of these complex glycoconjugates, it is crucial to develop a powerful analytic method to identify ginsenosides qualitatively or quantitatively. We herein report an eight-channel fluorescent sensor array as artificial tongue to achieve the discriminative sensing of ginsenosides. The fluorescent cross-responsive array was constructed by four boronlectins bearing flexible boronic acid moieties (FBAs) with multiple reactive sites and two linear poly(phenylene-ethynylene) (PPEs). An "on-off-on" response pattern was afforded on the basis of superquenching of fluorescent indicator PPEs and an analyte-induced allosteric indicator displacement (AID) process. Most importantly, it was found that the canonical distribution of ginsenoside data points analyzed by linear discriminant analysis (LDA) was highly correlated with the inherent molecular structures of the analytes, and the absence of overlaps among the five point groups reflected the effectiveness of the sensor array in the discrimination process. Almost all of the unknown ginsenoside samples at different concentrations were correctly identified on the basis of the established mathematical model. Our current work provided a general and constructive method to improve the quality assessment and control of ginseng and its extracts, which are useful and helpful for further discriminating other complex glycoconjugate families.
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/38062]
专题	化学研究所_有机固体实验室
作者单位	1.Beijing Normal Univ, Dept Chem, Beijing 100875, Peoples R China 2.Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Xiao-tai,Wang, Shu,Xing, Guo-wen. Boronlectin/Polyelectrolyte Ensembles as Artificial Tongue: Design, Construction, and Application for Discriminative Sensing of Complex Glycoconjugates from Panax ginseng[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(4):3368-3375.
APA	Zhang, Xiao-tai,Wang, Shu,&Xing, Guo-wen.(2017).Boronlectin/Polyelectrolyte Ensembles as Artificial Tongue: Design, Construction, and Application for Discriminative Sensing of Complex Glycoconjugates from Panax ginseng.ACS APPLIED MATERIALS & INTERFACES,9(4),3368-3375.
MLA	Zhang, Xiao-tai,et al."Boronlectin/Polyelectrolyte Ensembles as Artificial Tongue: Design, Construction, and Application for Discriminative Sensing of Complex Glycoconjugates from Panax ginseng".ACS APPLIED MATERIALS & INTERFACES 9.4(2017):3368-3375.