Cytotoxicity-Guided Isolation of Two New Phenolic Derivatives from Dryopteris fragrans (L.) Schott

doi:10.3390/molecules23071652

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Cytotoxicity-Guided Isolation of Two New Phenolic Derivatives from Dryopteris fragrans (L.) Schott
	Zhang, Tong 1; Wang, Li 2; Duan, De-Hua 1; Zhang, Yi-Hao 1; Huang, Sheng-Xiong2 ; Chang, Ying 1
刊名	MOLECULES
	2018-07-01
卷号	23 期号:7 页码:11
关键词	cytotoxicity-guided phenolic derivatives Dryopteris fragrans chemical derivatization immuno-regulation activity
ISSN号	1420-3049
DOI	10.3390/molecules23071652
英文摘要	Dryopteris fragrans is a valuable medicinal plant resource with extensive biological activities including anti-cancer, anti-oxidation, and anti-inflammation activities. This work aims to study further the cytotoxic constituents from Dryopteris fragrans. In this work, two new phenolic derivatives known as dryofragone (1) and dryofracoumarin B (2) with six known compounds (3-8) were isolated from the petroleum ether fraction of the methanol extract of the aerial parts of Dryopteris fragrans (L.) Schott by two round cytotoxicity-guided tracking with the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay and cell counting kit-8 (CCK-8) assay. Their structures were elucidated by the extensive spectroscopic analysis (H-1-NMR, C-13-NMR, and two dimensions NMR), chemical derivatization, and comparison with data reported in the literature. All the isolates were evaluated for their cytotoxicity against nine cancer cell lines as well as their in vitro immunomodulatory activity. The results showed that compounds have a modest cytotoxicity toward human HeLa cell line with IC50 value below 30 mu M and compounds 4 and 5 may modulate immunity to affect the growth of tumor cells.
资助项目	National Natural Science Foundation of China[31570189] ; National Natural Science Foundation of China[81522044] ; Applied Basic Research Foundation of Yunnan Province[2013HA022] ; Foundation from Chinese Academy of Sciences[QYZDB-SSW-SMC051]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	MDPI
WOS记录号	WOS:000445301800155
资助机构	National Natural Science Foundation of China ; Applied Basic Research Foundation of Yunnan Province ; Foundation from Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/62783]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Huang, Sheng-Xiong; Chang, Ying
作者单位	1.Northeast Agr Univ, Coll Life Sci, Harbin 150030, Heilongjiang, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Tong,Wang, Li,Duan, De-Hua,et al. Cytotoxicity-Guided Isolation of Two New Phenolic Derivatives from Dryopteris fragrans (L.) Schott[J]. MOLECULES,2018,23(7):11.
APA	Zhang, Tong,Wang, Li,Duan, De-Hua,Zhang, Yi-Hao,Huang, Sheng-Xiong,&Chang, Ying.(2018).Cytotoxicity-Guided Isolation of Two New Phenolic Derivatives from Dryopteris fragrans (L.) Schott.MOLECULES,23(7),11.
MLA	Zhang, Tong,et al."Cytotoxicity-Guided Isolation of Two New Phenolic Derivatives from Dryopteris fragrans (L.) Schott".MOLECULES 23.7(2018):11.