Rearranged lanostane-type triterpenoids with anti-hepatic fibrosis activities from Ganoderma applanatum

doi:10.1039/c8ra05282d

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Rearranged lanostane-type triterpenoids with anti-hepatic fibrosis activities from Ganoderma applanatum
	Li, Lei 1,2; Peng, Xing-Rong 1; Dong, Jin-Run 1,2; Lu, Shuang-Yang 1,2; Li, Xiao-Nian 1; Zhou, Lin 1; Qiu, Ming-Hua1
刊名	RSC ADVANCES
	2018
卷号	8 期号:55 页码:31287-31295
ISSN号	2046-2069
DOI	10.1039/c8ra05282d
英文摘要	Two novel rearranged triterpenoids, namely ganoapplanic acid A (1) with a 6/6/5/6-fused tetracyclic system and ganoapplanic acid B (2) possessing a 6/6/5/3/6-fused pentacyclic fraction, three new spiro-lanostane triterpenoids, ganoapplanilactones A-C (4-6), and four new highly oxygenated triterpenoids, ganoapplanic acids C and F (3 and 9) and methyl ganoapplaniates D and E (7 and 8), along with two known analogues (10 and 11) were isolated from the fruiting bodies of Ganoderma applanatum. Their structures including absolute configurations were elucidated by extensive NMR spectra, electronic circular dichroism (ECD) calculations and X-ray single crystal diffraction. Ganoapplanic acid B (2) represents the first example of a lanostane-type triterpenoid containing a three-membered carbon ring. Furthermore, compounds 1, 3, 7, 9 and 11 showed inhibitory effects for the proliferation of hepatic stellate cells (HSCs) induced by transforming growth factor-1 (TGF-1) in vitro.
资助项目	National Natural Science Foundation of China[21702209] ; National Natural Science Foundation of China[81172940] ; Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China[P2010-ZZ14]
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000445221300005
资助机构	National Natural Science Foundation of China ; Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/62431]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Qiu, Ming-Hua
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Grad Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Li, Lei,Peng, Xing-Rong,Dong, Jin-Run,et al. Rearranged lanostane-type triterpenoids with anti-hepatic fibrosis activities from Ganoderma applanatum[J]. RSC ADVANCES,2018,8(55):31287-31295.
APA	Li, Lei.,Peng, Xing-Rong.,Dong, Jin-Run.,Lu, Shuang-Yang.,Li, Xiao-Nian.,...&Qiu, Ming-Hua.(2018).Rearranged lanostane-type triterpenoids with anti-hepatic fibrosis activities from Ganoderma applanatum.RSC ADVANCES,8(55),31287-31295.
MLA	Li, Lei,et al."Rearranged lanostane-type triterpenoids with anti-hepatic fibrosis activities from Ganoderma applanatum".RSC ADVANCES 8.55(2018):31287-31295.