Aurovertin B sensitizes colorectal cancer cells to NK cell recognition and lysis

doi:10.1016/j.bbrc.2018.08.093

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Aurovertin B sensitizes colorectal cancer cells to NK cell recognition and lysis
	Zhu, Huifang 1,2; Wang, Fei 4; Ju, Xiaoman 1,2; Kong, Lingmei 1; An, Tao1 ; Zhao, Zhangxun 1,2; Liu, Jikai 3; Li, Yan1
刊名	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
	2018-09-18
卷号	503 期号:4 页码:3057-3063
关键词	Aurovertin B Cytotoxicity Immunotherapy NK cell NKG2D ligands
ISSN号	0006-291X
DOI	10.1016/j.bbrc.2018.08.093
英文摘要	The natural killer group 2D (NKG2D) receptor on natural killer (NK) cells play an important role in immunosurveillance to cancer cells, which could mediate the eradication of tumor cells through specific interactions with NKG2D ligands on tumor cells. Here we report one natural compound aurovertin B from basidiomycete Albatrellus confluens significantly stimulates the expression of NKG2D ligands on tumor cells, which greatly sensitizes its recognition and lysis by NK cell. It is completely a novel role for aurovertin B to target tumor cells to death mediated by NK cells and our findings indicate aurovertin B may deserve further development as sensitizing agent in NK cell mediated cancer immunotherapy. (C) 2018 Elsevier Inc. All rights reserved.
资助项目	Exploitation and Utilization of Abundant Natural Products from Plants from Kunming Institute of Botany[KIB2017009] ; National Natural Science Foundation of China[U1402227] ; 100 Talents Program of the Chinese Academy of Sciences ; Program of Recruited Top Talent of Sciences and Technology of Yunnan Province[2009CI120] ; Independent Program of Key Laboratory of Natural Pharmaceutical Chemistry of Yunnan Province
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000444791600129
资助机构	Exploitation and Utilization of Abundant Natural Products from Plants from Kunming Institute of Botany ; National Natural Science Foundation of China ; 100 Talents Program of the Chinese Academy of Sciences ; Program of Recruited Top Talent of Sciences and Technology of Yunnan Province ; Independent Program of Key Laboratory of Natural Pharmaceutical Chemistry of Yunnan Province
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/62416]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Liu, Jikai; Li, Yan
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.South Cent Univ Nationalities, Sch Pharmaceut Sci, 182 Minzu Rd, Wuhan 430074, Hubei, Peoples R China 4.BioBioPha Co Ltd, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Huifang,Wang, Fei,Ju, Xiaoman,et al. Aurovertin B sensitizes colorectal cancer cells to NK cell recognition and lysis[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2018,503(4):3057-3063.
APA	Zhu, Huifang.,Wang, Fei.,Ju, Xiaoman.,Kong, Lingmei.,An, Tao.,...&Li, Yan.(2018).Aurovertin B sensitizes colorectal cancer cells to NK cell recognition and lysis.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,503(4),3057-3063.
MLA	Zhu, Huifang,et al."Aurovertin B sensitizes colorectal cancer cells to NK cell recognition and lysis".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 503.4(2018):3057-3063.