Modified Abietane Diterpenoids from Whole Plants of Selaginella moellendorffii

doi:10.1021/acs.jnatprod.7b00909

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Modified Abietane Diterpenoids from Whole Plants of Selaginella moellendorffii
	Ke, Lei-Yu 1,2,3,4; Zhang, Yu1,2 ; Xia, Meng-Yuan 1,2,3; Zhuo, Jing-Xian 1,2; Wang, Yue-Hu1,2,3 ; Long, Chun-Lin 5
刊名	JOURNAL OF NATURAL PRODUCTS
	2018-02-01
卷号	81 期号:2 页码:418-422
ISSN号	0163-3864
DOI	10.1021/acs.jnatprod.7b00909
英文摘要	A new modified abietane diterpenoid, (3S,4S,5R,10S)-18(4 -> 3)-abeo-3,4,12,18-tetrahydroxy-8,11,13-abietatrien-7-one (1), and two novel dimers, selaginedorffones A (2) and B (3), featuring a new cyclohexene moiety that was biogenetically constructed from two modified abietane diterpenoids through a Diels-Alder reaction were obtained from a methanolic extract of Selaginella moellendorffii, a traditional Chinese herb. The structures of 1-3 were identified by a combination of NMR spectroscopic analysis and ECD calculations. In the present study, diterpenoids were identified from S. moellendorffii for the first time, which supports the presence of diterpene synthases in this plant. These three diterpenoids (1-3) were evaluated for HO their growth-inhibitory activities against several human cancer cell lines. Of these substances, selaginedorffone B (3) showed cytotoxicity against the MCF-7 human-breast-cancer-cell line (IC50 9.0 mu M).
语种	英语
WOS记录号	WOS:000426618300028
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/60536]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West C, Yunnan Key Lab Wild Plant Resources, Kunming 650201, Yunnan, Peoples R China 3.Chinese Acad Sci, Southeast Asia Biodivers Res Inst, Yezin 05282, Nay Pyi Taw, Myanmar 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China
推荐引用方式 GB/T 7714	Ke, Lei-Yu,Zhang, Yu,Xia, Meng-Yuan,et al. Modified Abietane Diterpenoids from Whole Plants of Selaginella moellendorffii[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(2):418-422.
APA	Ke, Lei-Yu,Zhang, Yu,Xia, Meng-Yuan,Zhuo, Jing-Xian,Wang, Yue-Hu,&Long, Chun-Lin.(2018).Modified Abietane Diterpenoids from Whole Plants of Selaginella moellendorffii.JOURNAL OF NATURAL PRODUCTS,81(2),418-422.
MLA	Ke, Lei-Yu,et al."Modified Abietane Diterpenoids from Whole Plants of Selaginella moellendorffii".JOURNAL OF NATURAL PRODUCTS 81.2(2018):418-422.