Seco-Dendrobine-Type Alkaloids and Bioactive Phenolics from Dendrobium findlayanum

doi:10.1021/acs.jnatprod.7b00150

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Seco-Dendrobine-Type Alkaloids and Bioactive Phenolics from Dendrobium findlayanum
	Yang, Dan 1,2,3,4; Cheng, Zhong-Quan 3; Yang, Liu 1,2; Hou, Bo 1,2; Yang, Jin 1,2; Li, Xiao-Nian 1,2; Zi, Cheng-Ting 1,2,4; Dong, Fa-Wu 1,2; Liu, Zheng-Hua 1,2; Zhou, Jun1,2
刊名	JOURNAL OF NATURAL PRODUCTS
	2018-02-01
卷号	81 期号:2 页码:227-235
ISSN号	0163-3864
DOI	10.1021/acs.jnatprod.7b00150
英文摘要	Investigation of the 95% EtOH extract of stems of Dendrobium findlayanum afforded four new seco-dendrobines, findlayines A-D (1-4); two known dendrobines, dendrobine (5) and 2-hydroxydendrobine (6); and four new phenolic compounds, dendrofindlaphenols A-C (7, 9, and 10) and 6 ''-de-O-rnethyldendrofindlaphenol A (8). Compounds 1 and 2 are the first seco-dendrobines possessing a seven membered lactam moiety, with 3 and 4 derived from the oxidative cleavage of the C-2-C-3 bond of dendrobine. The structures were established using spectroscopic methods and by comparison with literature data. The absolute configurations of 1-4 were confirmed via single-crystal X-ray diffraction data. Cytotoxic activity assays against HL-60, SMMC-7721, A-549, MCF-7, and SW480 human cancer cell lines revealed IC50 values ranging from 2.3 to 5.3 mu M for compound 7, from 19.4 to 34.4 mu M for 8, and from 49.4 to 96.8 mu g/mL for the EtOAc extract. An assay of the inhibition of NO production with RAW 264.7 cells indicated that 8 had an IC50 value of 21.4 mu M, and the EtOAc extract, 10.5 mu g/mL. The EtOAc extract possessed DPPH radical scavenging activity of 69.93% at 100 mu g/mL.
语种	英语
WOS记录号	WOS:000426618300002
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/60535]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 3.Guilin Normal Coll, Guilin 541001, Peoples R China 4.Yunnan Univ, Sch Chem Sci & Technol, Kunming 650091, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Yang, Dan,Cheng, Zhong-Quan,Yang, Liu,et al. Seco-Dendrobine-Type Alkaloids and Bioactive Phenolics from Dendrobium findlayanum[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(2):227-235.
APA	Yang, Dan.,Cheng, Zhong-Quan.,Yang, Liu.,Hou, Bo.,Yang, Jin.,...&Hu, Jiang-Miao.(2018).Seco-Dendrobine-Type Alkaloids and Bioactive Phenolics from Dendrobium findlayanum.JOURNAL OF NATURAL PRODUCTS,81(2),227-235.
MLA	Yang, Dan,et al."Seco-Dendrobine-Type Alkaloids and Bioactive Phenolics from Dendrobium findlayanum".JOURNAL OF NATURAL PRODUCTS 81.2(2018):227-235.