Isoindolinone-containing meroterpenoids with alpha-glucosidase inhibitory activity from mushroom Hericium caput-medusae

doi:10.1016/j.fitote.2017.08.017

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Isoindolinone-containing meroterpenoids with alpha-glucosidase inhibitory activity from mushroom Hericium caput-medusae
	Chen, Lin 1; Li, Zheng-Hui 1; Yao, Jian-Neng 2,3; Peng, Yue-Ling 1; Huang, Rong 1; Feng, Tao 1; Liu, Ji-Kai 1
刊名	FITOTERAPIA
	2017-10-01
卷号	122 页码:107-114
关键词	Hericium Caput-medusae Isoindolinone-containing Meroterpenoid Alpha-glucosidase Inhibition
ISSN号	0367-326X
DOI	10.1016/j.fitote.2017.08.017
英文摘要	Hericium caput-medusae is an edible and medicinal mushroom closely relative to H. erinaceus. According to our detailed chemical investigation, two novel isoindolinone-containing meroterpene dimers, caputmedusins A (1) and B (2), as well as nine analogues, caputmedusins G-K (3-11), were isolated from the fermentation broth of H. caput-medusae. Their structures were elucidated by analyses of 1D and 2D NMR spectroscopic methods. The absolute configurations of 1-4 were speculated based on the specific optical rotation and biogenetic consideration. The absolute configurations of lt) and 11 were rationalized by the calculation of H-1 NMR chemical shifts. Caputmedusins A-C (1-3) showed moderate inhibitory activity against a-glucosidase with the IC50 values of 39.2, 36.2 and 40.8 mu M, respectively.
语种	英语
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/60358]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Chen, Lin,Li, Zheng-Hui,Yao, Jian-Neng,et al. Isoindolinone-containing meroterpenoids with alpha-glucosidase inhibitory activity from mushroom Hericium caput-medusae[J]. FITOTERAPIA,2017,122:107-114.
APA	Chen, Lin.,Li, Zheng-Hui.,Yao, Jian-Neng.,Peng, Yue-Ling.,Huang, Rong.,...&Liu, Ji-Kai.(2017).Isoindolinone-containing meroterpenoids with alpha-glucosidase inhibitory activity from mushroom Hericium caput-medusae.FITOTERAPIA,122,107-114.
MLA	Chen, Lin,et al."Isoindolinone-containing meroterpenoids with alpha-glucosidase inhibitory activity from mushroom Hericium caput-medusae".FITOTERAPIA 122(2017):107-114.