In vitro Anti-Herpes Simplex Virus Activity of 1,2,4,6-Tetra-O-galloyl-beta-D-glucose from Phyllanthus emblica L. (Euphorbiaceae)

doi:10.1002/ptr.3368

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 中国科学院东亚植物多样性与生物地理学重点实验室

	In vitro Anti-Herpes Simplex Virus Activity of 1,2,4,6-Tetra-O-galloyl-beta-D-glucose from Phyllanthus emblica L. (Euphorbiaceae)
	Xiang, Yangfei 2; Pei, Ying 2; Qu, Chang 2; Lai, Zhicai 2; Ren, Zhe 2; Yang, Ke 2; Xiong, Sheng 2; Zhang, Yingjun3 ; Yang, Chongren 3; Wang, Dong3
刊名	PHYTOTHERAPY RESEARCH
	2011-07-01
卷号	25 期号:7 页码:975-982
关键词	Anti-herpes Simplex Virus Activity Hsv Polyphenol 1 PhyL.anthus EmbL.ca L. (Euphorbiaceae) 2 4 6-tetra-o-galloyl-beta-d-glucose
ISSN号	0951-418X
DOI	10.1002/ptr.3368
通讯作者	zhangyj@mail.kib.ac.cn ; kkholi@msn.com ; twang-yf@163.com
文献子类	Article
英文摘要	In this study, 1,2,4,6-tetra-O-galloyl-beta-D-glucose (1246TGG), a polyphenolic compound isolated from traditional Chinese medicine Phyllanthus emblica L. (Euphorbiaceae), was found to inhibit herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) infection at different magnitudes of activity in vitro. Further studies revealed that 1246TGG directly inactivated HSV-1 particles, leading to the failure of early infection, including viral attachment and penetration. 1246TGG also suppressed the intracellular growth of HSV-1 within a long period post-infection (from 0 h p.i. to 12 h p.i.), while it might exert an antiviral effect mainly before 3 h p.i. It inhibited HSV-1 E and L gene expressions as well as viral DNA replication but did not affect the RNA synthesis of IE gene in our study. Also, in the presence of 1246TGG, the synthesis of viral protein was reduced. Taken together, it was suggested that 1246TGG might exert anti-HSV activity both by inactivating extracellular viral particles and by inhibiting viral biosynthesis in host cells. These results warrant further studies on the antiviral mechanisms of 1246TGG and suggest that it might be a candidate for HSV therapy. Copyright (C) 2011 John Wiley & Sons, Ltd.
学科主题	Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS关键词	TYPE-1 ; ACYCLOVIR ; FLAVONOIDS ; FLAVANONE ; COMPOUND ; EUGENIIN ; GALLATE ; DRUGS
WOS研究方向	Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000293031400004
资助机构	National Science Foundation of China[U0632010]; State Key Laboratory of Phytochemistry and Plant Resources in West China, Chinese Academy of Sciences[P2008-KF07, P2008-ZZ08]; MOE[211]
公开日期	2012-03-16
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/3956]
专题	昆明植物研究所_中国科学院东亚植物多样性与生物地理学重点实验室
作者单位	1.Jinan Univ, Biomed Res & Dev Ctr, Guangdong Prov Key Lab Bioengn Med, Guangzhou 510632, Guangdong, Peoples R China 2.Jinan Univ, Natl Engn Res Ctr Genet Med, Guangzhou 510632, Guangdong, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming, Peoples R China 4.Nagasaki Univ, Grad Sch Biomed Sci, Dept Mol Microbiol & Immunol, Lab Mol Biol Infect Agents, Nagasaki 852, Japan
推荐引用方式 GB/T 7714	Xiang, Yangfei,Pei, Ying,Qu, Chang,et al. In vitro Anti-Herpes Simplex Virus Activity of 1,2,4,6-Tetra-O-galloyl-beta-D-glucose from Phyllanthus emblica L. (Euphorbiaceae)[J]. PHYTOTHERAPY RESEARCH,2011,25(7):975-982.
APA	Xiang, Yangfei.,Pei, Ying.,Qu, Chang.,Lai, Zhicai.,Ren, Zhe.,...&Wang, Yifei.(2011).In vitro Anti-Herpes Simplex Virus Activity of 1,2,4,6-Tetra-O-galloyl-beta-D-glucose from Phyllanthus emblica L. (Euphorbiaceae).PHYTOTHERAPY RESEARCH,25(7),975-982.
MLA	Xiang, Yangfei,et al."In vitro Anti-Herpes Simplex Virus Activity of 1,2,4,6-Tetra-O-galloyl-beta-D-glucose from Phyllanthus emblica L. (Euphorbiaceae)".PHYTOTHERAPY RESEARCH 25.7(2011):975-982.