Polycyclic Azetidines and Pyrrolidines via Palladium-Catalyzed Intramolecular Amination of Unactivated C(sp3)-H Bonds

doi:10.1021/acs.orglett.7b02339

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Polycyclic Azetidines and Pyrrolidines via Palladium-Catalyzed Intramolecular Amination of Unactivated C(sp3)-H Bonds
	Zhao, Jie 1,2; Zhao, Xiao-Jing 1,2; Cao, Pei 1; Liu, Ji-Kai 3; Wu, Bin 1,3
刊名	ORGANIC LETTERS
	2017-09-15
卷号	19 期号:18 页码:4880-4883
关键词	C-h Functionalization c(Sp(3))-h Bonds Beta-lactams Stereoselective-synthesis Organic-synthesis Aliphatic-amines Activation Derivatives Cyclization Amidation
ISSN号	1523-7060
DOI	10.1021/acs.orglett.7b02339
英文摘要	A novel strategy to construct complex poly cyclic nitrogen-containing heterocycles from aliphatic amines via picolinamide-assisted palladium-catalyzed C-H bond activation reaction was reported. The reaction exhibits broad substrate scope for the synthesis of various azabicyclic scaffolds, including azetidines and tropane-class alkaloids. Application of this method to naturally occurring (-)-cis-myrtanylamine, an unprecedented type of carbon-carbon bond activation, in which the electron-pair involved initiates an intramolecular "S(N)2-like" displacement of a cyclopalladium-fragment from a tertiary center, is described.
学科主题	Chemistry, Organic
语种	英语
WOS记录号	WOS:000411304300045
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/54881]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Jie,Zhao, Xiao-Jing,Cao, Pei,et al. Polycyclic Azetidines and Pyrrolidines via Palladium-Catalyzed Intramolecular Amination of Unactivated C(sp3)-H Bonds[J]. ORGANIC LETTERS,2017,19(18):4880-4883.
APA	Zhao, Jie,Zhao, Xiao-Jing,Cao, Pei,Liu, Ji-Kai,&Wu, Bin.(2017).Polycyclic Azetidines and Pyrrolidines via Palladium-Catalyzed Intramolecular Amination of Unactivated C(sp3)-H Bonds.ORGANIC LETTERS,19(18),4880-4883.
MLA	Zhao, Jie,et al."Polycyclic Azetidines and Pyrrolidines via Palladium-Catalyzed Intramolecular Amination of Unactivated C(sp3)-H Bonds".ORGANIC LETTERS 19.18(2017):4880-4883.