Monoterpenoid Indole Alkaloids from Alstonia yunnanensis

doi:10.1021/np900374s

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Monoterpenoid Indole Alkaloids from Alstonia yunnanensis
	Feng, Tao 1,2; Li, Yan1 ; Cai, Xiang-Hai1 ; Gong, Xun1 ; Liu, Ya-Ping 1,2; Zhang, Rong-Ting 1,2; Zhang, Xiang-Yun 1,2; Tan, Qin-Gang 1,2; Luo, Xiao-Dong1
刊名	JOURNAL OF NATURAL PRODUCTS
	2009-10-01
卷号	72 期号:10 页码:1836-1841
关键词	Cultures Antifungal Metabolite Couplings
ISSN号	0163-3864
DOI	10.1021/np900374s
文献子类	Article
英文摘要	Eight new monoterpenoid indole alkaloids, alstoyunines A-H (1-8), along with 17 known analogues, were isolated from Alstonia yunnanensis. The structures of. the new alkaloids were established by means of extensive spectroscopic methods. Alstoyunines C (3), E (5), and F (6) showed selective inhibition of Cox-2 (>75%). Alstoyunine F (6) showed weak cytotoxicity against the human myeloid leukemia HL-60 (IC(50) = 3.89 mu M) and hepatocellular carcinoma SMMC-7721 (IC(50) = 21.73 mu M) cell lines.
学科主题	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS关键词	ABSOLUTE STEREOCHEMISTRY ; VENENATA RBR ; LEAVES ; 19-EPIAJMALICINE ; RAUCAFFRINOLINE ; PROLIFERATION ; LOCHNERICINE ; SCHOLARIS ; PLANTS
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000271950400017
资助机构	National Basic Research Program of China [2009CB522300]; Chinese Academy of Science [KZCX2-XB2-15]
公开日期	2012-03-21
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/4794]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Feng, Tao,Li, Yan,Cai, Xiang-Hai,et al. Monoterpenoid Indole Alkaloids from Alstonia yunnanensis[J]. JOURNAL OF NATURAL PRODUCTS,2009,72(10):1836-1841.
APA	Feng, Tao.,Li, Yan.,Cai, Xiang-Hai.,Gong, Xun.,Liu, Ya-Ping.,...&Luo, Xiao-Dong.(2009).Monoterpenoid Indole Alkaloids from Alstonia yunnanensis.JOURNAL OF NATURAL PRODUCTS,72(10),1836-1841.
MLA	Feng, Tao,et al."Monoterpenoid Indole Alkaloids from Alstonia yunnanensis".JOURNAL OF NATURAL PRODUCTS 72.10(2009):1836-1841.