Volvalerenone A, a new type of mononorsesquiterpenoid with an unprecedented 3,12-oxo bridge from Valeriana officinalis

doi:10.1016/j.tetlet.2010.08.023

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Volvalerenone A, a new type of mononorsesquiterpenoid with an unprecedented 3,12-oxo bridge from Valeriana officinalis
	Wang, Peng-Cheng 1,3; Ran, Xin-Hui 1; Chen, Rui 1; Li, Liang-Chun 4; Xiong, Shan-Shan 5; Liu, Yu-Qing 1; Luo, Huai-Rong1 ; Zhou, Jun1 ; Zhao, You-Xing 1,2
刊名	TETRAHEDRON LETTERS
	2010-10-13
卷号	51 期号:41 页码:5451-5453
关键词	Valeriana Officinalis Valerianacae Mononorsesquiterpenoid Volvalerenone a Ache Inhibitory Activity
ISSN号	0040-4039
DOI	10.1016/j.tetlet.2010.08.023
文献子类	Article
英文摘要	Volvalerenone A (1), a new type of mononorsesquiterpenoid with an unprecedented 5/6/6 tricyclic ring system, was isolated from the roots of Valeriana officinalis, the official species of valerian used in Europe. The structure of volvalerenone A was elucidated based on its spectroscopic and single-crystal X-ray crystallography data. The absolute configuration was assigned by the computational method. A possible bio-synthetic pathway of volvalerenone A was also proposed. Preliminary biological studies showed that volvalerenone A had weak inhibitory activity on acetylcholine esterase (AChE), and no enhancing activity on nerve growth factor (NGF)-mediated neurite outgrowth in PC12 cells was observed at 50 mu M. (C) 2010 Elsevier Ltd. All rights reserved.
学科主题	Chemistry, Organic
WOS关键词	VALERENIC ACID ; JATAMANSI ; IRIDOIDS ; ROOTS ; SESQUITERPENOIDS ; INHIBITOR
WOS研究方向	Chemistry
语种	英语
WOS记录号	WOS:000282381000026
资助机构	State Key Laboratory of Phytochemistry and Plant Resources in West China [P2008-ZZ22]; Natural Science foundation of Yunnan [2008CD 159]
公开日期	2012-03-21
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/4314]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 4.Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China 5.Yunnan Univ, Dept Chem, Kunming 650091, Peoples R China
推荐引用方式 GB/T 7714	Wang, Peng-Cheng,Ran, Xin-Hui,Chen, Rui,et al. Volvalerenone A, a new type of mononorsesquiterpenoid with an unprecedented 3,12-oxo bridge from Valeriana officinalis[J]. TETRAHEDRON LETTERS,2010,51(41):5451-5453.
APA	Wang, Peng-Cheng.,Ran, Xin-Hui.,Chen, Rui.,Li, Liang-Chun.,Xiong, Shan-Shan.,...&Zhao, You-Xing.(2010).Volvalerenone A, a new type of mononorsesquiterpenoid with an unprecedented 3,12-oxo bridge from Valeriana officinalis.TETRAHEDRON LETTERS,51(41),5451-5453.
MLA	Wang, Peng-Cheng,et al."Volvalerenone A, a new type of mononorsesquiterpenoid with an unprecedented 3,12-oxo bridge from Valeriana officinalis".TETRAHEDRON LETTERS 51.41(2010):5451-5453.