Effects of spiramine T on antioxidant enzymatic activities and nitric oxide production in cerebral ischemia-reperfusion gerbils

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Effects of spiramine T on antioxidant enzymatic activities and nitric oxide production in cerebral ischemia-reperfusion gerbils
	Li, L; Shen, YM ; Yang, XS ; Wu, WL ; Wang, BG ; Chen, ZH ; Hao, XJ
刊名	BRAIN RESEARCH
	2002-07-19
卷号	944 期号:1-2 页码:205-209
关键词	Spiraea Japonica Var. Acuta Rosaceae Spiramine t Cerebral Ischemia-reperfusion Antioxidant Enzyme Nitric Oxide Synthase
ISSN号	0006-8993
文献子类	Article
英文摘要	Spiramine T, an atisine-type diterpene alkaloid isolated from the Chinese herbal medicine Spiraea japonica var. acuta (Rosaceae), was shown to have neuroprotective effects on cerebral ischemia-reperfusion injury. In this study, the effects of spiramine T on antioxidant enzymes and nitric oxide production were evaluated in gerbils subjected to global forebrain ischemia (10 min) and reperfusion (5 days). Spiramine T (1.0 and 2.0 mg kg(-1) i.p.) markedly reduced the content of lipid peroxide (LPO), increased the glutathione peroxidase (GSH-PX) activity, and inhibited the increase of nitric oxidase (NOS) activity and nitric oxide production in the cortex during ischemia-reperfusion in gerbils. These results suggested that the neuroprotective effects of spiramine T were related to modulation of endogenous antioxidant enzymatic activities and reduction of the formation of nitric oxide. (C) 2002 Elsevier Science B.V. All rights reserved.
学科主题	Neurosciences
WOS关键词	SPIRAEA-JAPONICA ; GLUTATHIONE-PEROXIDASE ; SUPEROXIDE-DISMUTASE ; ARTERY OCCLUSION ; TRANSGENIC MICE ; BRAIN INJURY ; SYNTHASE ; ALKALOIDS ; INDUCTION ; PROTECTS
WOS研究方向	Neurosciences & Neurology
语种	英语
WOS记录号	WOS:000177224100023
公开日期	2012-03-21
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/4132]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Yunnan, Peoples R China 2.Kunming Med Coll, Yunnan Pharmacol Labs Nat Prod, Kunming 650031, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Li, L,Shen, YM,Yang, XS,et al. Effects of spiramine T on antioxidant enzymatic activities and nitric oxide production in cerebral ischemia-reperfusion gerbils[J]. BRAIN RESEARCH,2002,944(1-2):205-209.
APA	Li, L.,Shen, YM.,Yang, XS.,Wu, WL.,Wang, BG.,...&Hao, XJ.(2002).Effects of spiramine T on antioxidant enzymatic activities and nitric oxide production in cerebral ischemia-reperfusion gerbils.BRAIN RESEARCH,944(1-2),205-209.
MLA	Li, L,et al."Effects of spiramine T on antioxidant enzymatic activities and nitric oxide production in cerebral ischemia-reperfusion gerbils".BRAIN RESEARCH 944.1-2(2002):205-209.