Antifungal activity of C-27 steroidal saponins

doi:10.1128/AAC.50.5.1710-1714.2006

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Antifungal activity of C-27 steroidal saponins
	Yang, CR ; Zhang, Y; Jacob, MR ; Khan, SI ; Zhang, YJ; Li, XC
刊名	ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
	2006-05-01
卷号	50 期号:5 页码:1710-1714
关键词	Fermented Leaves Agave-americana Candida-albicans Glycosides Resistance
ISSN号	0066-4804
DOI	10.1128/AAC.50.5.1710-1714.2006
通讯作者	zhangyj@mail.kib.ac.cn ; xcli7@olemiss.edu
文献子类	Article
英文摘要	As part of our search for new antifungal agents from natural resources, 22 C-27 steroidal saponins and 6 steroidal sapogenins isolated from several monocotyledonous plants were tested for their antifungal activity against the opportunistic pathogens Candida albicans, Candida glabrata, Candida krusei, Cryptococcus neoformans, and Aspergillus fumigatus. The results showed that the antifungal activity of the steroidal saponins was associated with their aglycone moieties and the number and structure of monosaccharide units in their sugar chains. Within the 10 active saponins, four tigogenin saponins (compounds I to 4) with a sugar moiety of four or five monosaccharide units exhibited significant activity against C. neoformans and A. fumigatus, comparable to the positive control amphotericin B. The antifungal potency of these compounds was not associated with cytotoxicity to mammalian cells. This suggests that the C-27 steroidal saponins may be considered potential antifungal leads for further preclinical study.
学科主题	Microbiology ; Pharmacology & Pharmacy
WOS关键词	FERMENTED LEAVES ; AGAVE-AMERICANA ; CANDIDA-ALBICANS ; GLYCOSIDES ; RESISTANCE
WOS研究方向	Microbiology ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000237365300014
公开日期	2011-12-19
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/2925]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.CAS, Kunming Inst Bot, Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Univ Mississippi, Sch Pharm, Pharmaceut Sci Res Inst, Natl Ctr Nat Prod Res, University, MS 38677 USA
推荐引用方式 GB/T 7714	Yang, CR,Zhang, Y,Jacob, MR,et al. Antifungal activity of C-27 steroidal saponins[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,2006,50(5):1710-1714.
APA	Yang, CR,Zhang, Y,Jacob, MR,Khan, SI,Zhang, YJ,&Li, XC.(2006).Antifungal activity of C-27 steroidal saponins.ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,50(5),1710-1714.
MLA	Yang, CR,et al."Antifungal activity of C-27 steroidal saponins".ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 50.5(2006):1710-1714.